Literature DB >> 15999986

p53 Activation by small molecules: application in oncology.

Lyubomir T Vassilev1.   

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Year:  2005        PMID: 15999986     DOI: 10.1021/jm058174k

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


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  56 in total

1.  Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.

Authors:  Drew D Dudgeon; Sunita N Shinde; Tong Ying Shun; John S Lazo; Christopher J Strock; Kenneth A Giuliano; D Lansing Taylor; Patricia A Johnston; Paul A Johnston
Journal:  Assay Drug Dev Technol       Date:  2010-08       Impact factor: 1.738

2.  A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.

Authors:  Hongbo Wang; Xujun Ma; Shumei Ren; John K Buolamwini; Chunhong Yan
Journal:  Mol Cancer Ther       Date:  2010-11-12       Impact factor: 6.261

3.  Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation.

Authors:  Erica M Walsh; MengMeng Niu; Johann Bergholz; Zhi-Xiong Jim Xiao
Journal:  Biochem Biophys Res Commun       Date:  2015-04-12       Impact factor: 3.575

4.  Protein-protein interactions for cancer therapy.

Authors:  Curtis C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-01       Impact factor: 11.205

5.  A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.

Authors:  Hongbo Wang; Chunhong Yan
Journal:  Neoplasia       Date:  2011-07       Impact factor: 5.715

6.  Beta-peptides with improved affinity for hDM2 and hDMX.

Authors:  Elizabeth A Harker; Douglas S Daniels; Danielle A Guarracino; Alanna Schepartz
Journal:  Bioorg Med Chem       Date:  2009-01-23       Impact factor: 3.641

7.  Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.

Authors:  Tyler A Davis; Anna E Vilgelm; Ann Richmond; Jeffrey N Johnston
Journal:  J Org Chem       Date:  2013-10-15       Impact factor: 4.354

8.  Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.

Authors:  Kensuke Kumamoto; Elisa A Spillare; Kaori Fujita; Izumi Horikawa; Taro Yamashita; Ettore Appella; Makoto Nagashima; Seiichi Takenoshita; Jun Yokota; Curtis C Harris
Journal:  Cancer Res       Date:  2008-05-01       Impact factor: 12.701

Review 9.  The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction.

Authors:  Kaushik Panigrahi; MariJean Eggen; Jun-Ho Maeng; Quanrong Shen; David B Berkowitz
Journal:  Chem Biol       Date:  2009-09-25

10.  TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.

Authors:  Shinako Araki; Jacob A Eitel; Christopher N Batuello; Khadijeh Bijangi-Vishehsaraei; Xian-Jin Xie; David Danielpour; Karen E Pollok; David A Boothman; Lindsey D Mayo
Journal:  J Clin Invest       Date:  2009-12-01       Impact factor: 14.808

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