Literature DB >> 15996911

Crystallization and preliminary crystallographic studies of the recombinant antitumour lectin from the edible mushroom Agrocybe aegerita.

Na Yang1, Xin Tong, Ye Xiang, Ying Zhang, Hui Sun, Da-Cheng Wang.   

Abstract

The antitumour lectin from Agrocybe aegerita, named AAL, shows strong inhibition effects on human and mouse tumour cells via apoptosis induction activity. Recombinant AAL (rAAL) has been expressed and purified. Both rAAL and rAAL-lactose complex have been crystallized and their X-ray diffraction data were collected to resolutions of 1.9 A and 1.6 A, respectively. Both crystals belong to space group P2(1) with unit cell parameters a = 53.20 A, b = 66.01 A, c = 57.86 A, beta = 109.38 and a = 53.38 A, b = 66.29 A, c = 58.02 A, beta = 109.03, respectively.

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Year:  2005        PMID: 15996911     DOI: 10.1016/j.bbapap.2005.06.003

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  4 in total

1.  Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen.

Authors:  Lei Feng; Hui Sun; Ying Zhang; De-Feng Li; Da-Cheng Wang
Journal:  FASEB J       Date:  2010-06-07       Impact factor: 5.191

2.  Headspace-Solid-Phase Microextraction-Gas Chromatography as Analytical Methodology for the Determination of Volatiles in Wild Mushrooms and Evaluation of Modifications Occurring during Storage.

Authors:  Rosaria Costa; Selenia De Grazia; Elisa Grasso; Alessandra Trozzi
Journal:  J Anal Methods Chem       Date:  2015-04-07       Impact factor: 2.193

3.  Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

Authors:  Yanxia Jin; Jie Wang; Xiangdong Ye; Yanting Su; Guojun Yu; Qing Yang; Wei Liu; Wenhui Yu; Jie Cai; Xi Chen; Yi Liang; Yijie Chen; Barry Hon Cheung Wong; Xiangning Fu; Hui Sun
Journal:  Br J Cancer       Date:  2016-02-23       Impact factor: 7.640

4.  3'-Sulfo-TF Antigen Determined by GAL3ST2/ST3GAL1 Is Essential for Antitumor Activity of Fungal Galectin AAL/AAGL.

Authors:  Yang Li; Yan Li; Jing Xia; Qing Yang; Yijie Chen; Hui Sun
Journal:  ACS Omega       Date:  2021-07-01
  4 in total

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