Literature DB >> 15994833

Role of CXCR3 in the immune response to murine gammaherpesvirus 68.

Bong Joo Lee1, Francesca Giannoni, Ashley Lyon, Shinichiro Yada, Bao Lu, Craig Gerard, Sally R Sarawar.   

Abstract

The chemokine IP-10 (CXCL10) and its cellular receptor CXCR3 are upregulated in the lung during murine gammaherpesvirus 68 (MHV-68) infection. In order to determine the role of the CXCR3 chemokine receptor in the immune response to MHV-68, CXCR3-/- mice were infected with the virus. CXCR3-/- mice showed delayed clearance of replicating MHV-68 from the lungs. This correlated with delayed T-cell recruitment to the lungs and reduced cytolytic activity prior to viral clearance. Splenomegaly and the numbers of latently infected cells per spleen were transiently increased. However, CXCR3-/- mice showed normal virus-specific antibody titers and effective long-term control of MHV-68 infection.

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Year:  2005        PMID： 15994833      PMCID： PMC1168727          DOI： 10.1128/JVI.79.14.9351-9355.2005

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

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