| Literature DB >> 15981418 |
Kaneo Kanoh, Yoshihide Matsuo, Kyoko Adachi, Hiroshi Imagawa, Mugio Nishizawa, Yoshikazu Shizuri.
Abstract
A new cytotoxic substance named mechercharmycin A was isolated from marine-derived Thermoactinomyces sp. YM3-251. The structure of mechercharmycin A was determined by an X-ray crystallographic analysis to be cyclic peptide-like and bearing four oxazoles and a thiazole. Mechercharmycin B, a linear congener of mechercharmycin A, was also isolated from the same bacterium. Mechercharmycin A exhibited relatively strong antitumor activity, whereas mechercharmycin B exhibited almost no such activity.Entities:
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Year: 2005 PMID： 15981418 DOI： 10.1038/ja.2005.36
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649