| Literature DB >> 15980397 |
John H Tran1, George A Jacoby, David C Hooper.
Abstract
Purified QnrA blocked ciprofloxacin inhibition of topoisomerase IV, just as QnrA was previously found to prevent quinolone inhibition of DNA gyrase. With a gel displacement assay, tagged QnrA was shown to bind to topoisomerase IV and its subunits in a reaction that did not depend on the presence of DNA, quinolone, or ATP.Entities:
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Year: 2005 PMID: 15980397 PMCID: PMC1168640 DOI: 10.1128/AAC.49.7.3050-3052.2005
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191