Literature DB >> 15979235

Anti-proliferative activity of essential oil extracted from Thai medicinal plants on KB and P388 cell lines.

Jiradej Manosroi1, Pongsathorn Dhumtanom, Aranya Manosroi.   

Abstract

Anti-proliferative activity of essential oil from 17 Thai medicinal plants on human mouth epidermal carcinoma (KB) and murine leukemia (P388) cell lines using MTT assay were investigated. An amount of 1 x 10(4)cells/well of KB cell line and 1 x 10(5) cells/well of P388 cell line were treated with the oil samples at different concentrations ranging from 0.019 to 4.962 mg/ml. In KB cell line, Guava (Psidium guajava L.) leaf oil showed the highest anti-proliferative activity with the IC(50) value of 0.0379 mg/ml (4.37 times more potent than vincristine) whereas Sweet Basil (Ocimum basilicum L.) oil gave the highest anti-proliferative activity with the IC(50) value of 0.0362 mg/ml (12.7 times less potent than 5-FU) in P388 cell line. The results demonstrated the potential of essential oil from Thai medicinal plants for cancer treatment.

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Year:  2005        PMID： 15979235     DOI： 10.1016/j.canlet.2005.04.021

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  38 in total

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10.  Total phenolics level, antioxidant activities and cytotoxicity of young sprouts of some traditional Korean salad plants.

Authors:  Sang-Uk Chon; Buk-Gu Heo; Yong-Seo Park; Dong-Kwan Kim; Shela Gorinstein
Journal:  Plant Foods Hum Nutr       Date:  2009-03       Impact factor: 3.921
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