Literature DB >> 15979202

Worldwide polymorphism at the MC1R locus and normal pigmentation variation in humans.

Kateryna Makova1, Heather Norton.   

Abstract

While there have been many advances in our understanding of the genetics of pathological skin pigmentation in humans, our knowledge about what determines variation in normal skin color is still incomplete. Variation in one gene, melanocortin 1 receptor (MC1R), has been associated with red hair and fair skin in Europeans. However, this gene might also play an important role in shaping pigmentation of other human populations, where it experiences different selective pressures. Below we review what is currently known about polymorphism and selection at the MC1R coding and promoter regions in human populations, the pattern of MC1R evolution in nonhuman primates, and the interaction of MC1R with other genes.

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Year:  2005        PMID： 15979202     DOI： 10.1016/j.peptides.2004.12.032

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  21 in total

1.  Identifying genes underlying skin pigmentation differences among human populations.

Authors:  Sean Myles; Mehmet Somel; Kun Tang; Janet Kelso; Mark Stoneking
Journal:  Hum Genet       Date:  2006-09-15       Impact factor: 4.132

2.  Human skin pigmentation, migration and disease susceptibility.

Authors:  Nina G Jablonski; George Chaplin
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-03-19       Impact factor: 6.237

3.  A local duplication of the Melanocortin receptor 1 locus in Astyanax.

Authors:  Joshua B Gross; James Weagley; Bethany A Stahl; Li Ma; Luis Espinasa; Suzanne E McGaugh
Journal:  Genome       Date:  2017-07-24       Impact factor: 2.166

4.  Polymorphisms of four pigmentation genes (SLC45A2, SLC24A5, MC1R and TYRP1) among eleven endogamous populations of India.

Authors:  Meeta Mukherjee; Sanjukta Mukerjee; Neeta Sarkar-Roy; Tania Ghosh; D Kalpana; Anil Kumar Sharma
Journal:  J Genet       Date:  2013-04       Impact factor: 1.166

5.  Colloquium paper: human skin pigmentation as an adaptation to UV radiation.

Authors:  Nina G Jablonski; George Chaplin
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-05       Impact factor: 11.205

Review 6.  Adaptations to local environments in modern human populations.

Authors:  Choongwon Jeong; Anna Di Rienzo
Journal:  Curr Opin Genet Dev       Date:  2014-08-15       Impact factor: 5.578

7.  Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation.

Authors:  Melissa Edwards; Abigail Bigham; Jinze Tan; Shilin Li; Agnes Gozdzik; Kendra Ross; Li Jin; Esteban J Parra
Journal:  PLoS Genet       Date:  2010-03-05       Impact factor: 5.917

8.  The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans.

Authors:  Karin Loser; Thomas Brzoska; Vinzenz Oji; Matteo Auriemma; Maik Voskort; Verena Kupas; Lars Klenner; Cornelius Mensing; Axel Hauschild; Stefan Beissert; Thomas A Luger
Journal:  PLoS One       Date:  2010-02-01       Impact factor: 3.240

9.  Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians.

Authors:  Kazuhiro Nakayama; Augustinus Soemantri; Feng Jin; Bumbein Dashnyam; Ryutaro Ohtsuka; Phaibool Duanchang; Mohd Nizam Isa; Wannapa Settheetham-Ishida; Shinji Harihara; Takafumi Ishida
Journal:  Hum Genet       Date:  2006-02-04       Impact factor: 4.132

Review 10.  Genome-wide scans for footprints of natural selection.

Authors:  Taras K Oleksyk; Michael W Smith; Stephen J O'Brien
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-01-12       Impact factor: 6.237
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