| Literature DB >> 15975047 |
Jean Michel Brunel1, Chanaz Salmi, Celine Loncle, Nicolas Vidal, Yves Letourneux.
Abstract
The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?Entities:
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Year: 2005 PMID： 15975047 DOI： 10.2174/1568009054064642
Source DB: PubMed Journal: Curr Cancer Drug Targets ISSN： 1568-0096 Impact factor: 3.428