| Literature DB >> 15974608 |
Suresh Awale1, Suraj Prakash Shrestha, Yasuhiro Tezuka, Jun-ya Ueda, Katsumichi Matsushige, Shigetoshi Kadota.
Abstract
A methanolic extract of Nepalese propolis yielded 10 new open-chain neoflavonoids (1-10), a new chalcone (11), and eight previously reported compounds (12-19). Their structures were determined on the basis of spectroscopic data and chemical conversion. The isolated compounds other than 5, 8, and 16 showed dose-dependent inhibitory activities on nitric oxide production in lipopolysaccharide-activated macrophage-like J774.1 cells and were more active than a positive control, N(G)-monomethyl-L-arginine (IC(50), 27.1 microM). The most potent activities, of 6 and 7 (IC(50), 0.5 microM), were greater than another positive control, caffeic acid phenethyl ester (IC(50), 4.8 microM).Entities:
Mesh：
Substances：
Year: 2005 PMID： 15974608 DOI： 10.1021/np050009k
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050