OBJECTIVE: To determine the relationship between the virus burden in infancy and hearing loss in congenital CMV infection. STUDY DESIGN: A cohort of 76 infants with congenital cytomegalovirus (CMV) infection identified by means of newborn virologic screening was monitored for outcome. The amount of infectious CMV was analyzed in urine specimens obtained during early infancy. Peripheral blood (PB) samples obtained during early infancy were available from 75 children and CMV DNA was quantitated with a real-time quantitative polymerase chain reaction. RESULTS: Infants with clinical abnormalities at birth (symptomatic congenital CMV infection) had higher amounts of CMV in urine (P = .005) and CMV DNA in PB (P = .001) than infants with no symptoms. Eight children with and 4 children without symptoms had hearing loss. Among children without symptoms, those with hearing loss had a significantly greater amount of CMV in urine (P = .03) and PB virus burden (P = .02) during infancy than those with normal hearing. Infants with < 5 x 10(3) pfu/mL of urine CMV and infants with < 1 x 10(4) copies/mL of viral DNA in PB were at a lower risk for hearing loss. CONCLUSION: In children with asymptomatic congenital CMV infection, hearing loss was associated with increased amounts of urine CMV and PB CMV DNA during early infancy.
OBJECTIVE: To determine the relationship between the virus burden in infancy and hearing loss in congenital CMV infection. STUDY DESIGN: A cohort of 76 infants with congenital cytomegalovirus (CMV) infection identified by means of newborn virologic screening was monitored for outcome. The amount of infectious CMV was analyzed in urine specimens obtained during early infancy. Peripheral blood (PB) samples obtained during early infancy were available from 75 children and CMV DNA was quantitated with a real-time quantitative polymerase chain reaction. RESULTS:Infants with clinical abnormalities at birth (symptomatic congenital CMV infection) had higher amounts of CMV in urine (P = .005) and CMV DNA in PB (P = .001) than infants with no symptoms. Eight children with and 4 children without symptoms had hearing loss. Among children without symptoms, those with hearing loss had a significantly greater amount of CMV in urine (P = .03) and PB virus burden (P = .02) during infancy than those with normal hearing. Infants with < 5 x 10(3) pfu/mL of urine CMV and infants with < 1 x 10(4) copies/mL of viral DNA in PB were at a lower risk for hearing loss. CONCLUSION: In children with asymptomatic congenital CMV infection, hearing loss was associated with increased amounts of urine CMV and PB CMV DNA during early infancy.
Authors: Jennifer D Stowell; Daniela Forlin-Passoni; Erica Din; Kay Radford; Denise Brown; Audrey White; Sheri L Bate; Sheila C Dollard; Stephanie R Bialek; Michael J Cannon; D Scott Schmid Journal: J Infect Dis Date: 2011-11-23 Impact factor: 5.226
Authors: Clayton O Onyango; Vladimir Loparev; Shirley Lidechi; Vinod Bhullar; D Scott Schmid; Kay Radford; Michael K Lo; Paul Rota; Barbara W Johnson; Jorge Munoz; Martina Oneko; Deron Burton; Carolyn M Black; John Neatherlin; Joel M Montgomery; Barry Fields Journal: J Clin Microbiol Date: 2017-04-12 Impact factor: 5.948
Authors: Sharon F Chen; Tyson H Holmes; Teri Slifer; Vasavi Ramachandran; Sally Mackey; Cathleen Hebson; Ann M Arvin; David B Lewis; Cornelia L Dekker Journal: J Pediatric Infect Dis Soc Date: 2014-09-11 Impact factor: 3.164
Authors: Gai L McMichael; Amanda R Highet; Catherine S Gibson; Paul N Goldwater; Michael E O'Callaghan; Emily R Alvino; Alastair H MacLennan Journal: J Biomol Tech Date: 2011-04