OBJECTIVES: We sought to investigate the potential value of magnetic resonance (MR) elastography to improve the differentiation between benign and malignant tumors. MATERIAL AND METHODS: Measurements of 5 patients with 6 malignant lesions, 11 patients with benign lesions, and 4 patients with no lesions at all were performed at 1.5 Tesla. After breast MR imaging, MR elastography was performed as a targeted measurement. Low-frequency mechanical waves (65 Hz) were transmitted into the breast tissue using an oscillator and were displayed by means of a MR sequence within the phase of the MR image. After reconstruction, the viscoelastic information was correlated with the signal intensity and morphology data. RESULTS: All examinations were technically successful realized in approximately 25 minutes. Malignant tumors documented higher values of elasticity than benign corresponding with signal intensity and morphologic data. CONCLUSION: A good separation exists between benign and malignant lesions in elasticity, corresponding with specific signal intensity and morphologic data. Further clinical studies with a larger number of patients are needed for extended validation.
OBJECTIVES: We sought to investigate the potential value of magnetic resonance (MR) elastography to improve the differentiation between benign and malignant tumors. MATERIAL AND METHODS: Measurements of 5 patients with 6 malignant lesions, 11 patients with benign lesions, and 4 patients with no lesions at all were performed at 1.5 Tesla. After breast MR imaging, MR elastography was performed as a targeted measurement. Low-frequency mechanical waves (65 Hz) were transmitted into the breast tissue using an oscillator and were displayed by means of a MR sequence within the phase of the MR image. After reconstruction, the viscoelastic information was correlated with the signal intensity and morphology data. RESULTS: All examinations were technically successful realized in approximately 25 minutes. Malignant tumors documented higher values of elasticity than benign corresponding with signal intensity and morphologic data. CONCLUSION: A good separation exists between benign and malignant lesions in elasticity, corresponding with specific signal intensity and morphologic data. Further clinical studies with a larger number of patients are needed for extended validation.
Authors: Thomas Schlossbauer; Gerda Leinsinger; Axel Wismuller; Oliver Lange; Michael Scherr; Anke Meyer-Baese; Maximilian Reiser Journal: Invest Radiol Date: 2008-01 Impact factor: 6.016
Authors: Elijah E W Van Houten; D vR Viviers; M D J McGarry; P R Perriñez; I I Perreard; J B Weaver; K D Paulsen Journal: Med Phys Date: 2011-04 Impact factor: 4.071
Authors: John C Brigham; Wilkins Aquino; Miguel A Aguilo; Peter J Diamessis Journal: Comput Methods Appl Mech Eng Date: 2011-01-15 Impact factor: 6.756
Authors: Oh In Kwon; Chunjae Park; Hyun Soo Nam; Eung Je Woo; Jin Keun Seo; K J Glaser; A Manduca; R L Ehman Journal: IEEE Trans Med Imaging Date: 2009-10 Impact factor: 10.048