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Literature DB >> 15972535

Role of the distal sarA promoters in SarA expression in Staphylococcus aureus.

Abstract

The global regulatory locus sarA comprises a 375-bp open reading frame that is driven by three promoters, the proximal P1 and distal P3 and P2 promoters. We mutated the weaker P3 and P2 promoters to ascertain the effect of the change on SarA protein and target gene expression. Our results indicated that the solely active P1 promoter led to a lower SarA protein level, which has an effect on agr transcription and subsequently had corresponding effects on hla, sspA, and spa transcription, probably in both agr-independent and agr-dependent manners.

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Year: 2005 PMID： 15972535 PMCID： PMC1168551 DOI： 10.1128/IAI.73.7.4391-4394.2005

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

1. Characterization of sarR, a modulator of sar expression in Staphylococcus aureus.

Authors: A Manna; A L Cheung
Journal: Infect Immun Date: 2001-02 Impact factor: 3.441

2. Characterization of the SarA virulence gene regulator of Staphylococcus aureus.

Authors: T M Rechtin; A F Gillaspy; M A Schumacher; R G Brennan; M S Smeltzer; B K Hurlburt
Journal: Mol Microbiol Date: 1999-07 Impact factor: 3.501

3. Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci.

Authors: P M Dunman; E Murphy; S Haney; D Palacios; G Tucker-Kellogg; S Wu; E L Brown; R J Zagursky; D Shlaes; S J Projan
Journal: J Bacteriol Date: 2001-12 Impact factor: 3.490

4. SarT, a repressor of alpha-hemolysin in Staphylococcus aureus.

Authors: K A Schmidt; A C Manna; S Gill; A L Cheung
Journal: Infect Immun Date: 2001-08 Impact factor: 3.441

Review 5. Autoinduction and signal transduction in the regulation of staphylococcal virulence.

Authors: Richard P Novick
Journal: Mol Microbiol Date: 2003-06 Impact factor: 3.501

6. Characterization of the sar locus and its interaction with agr in Staphylococcus aureus.

Authors: J H Heinrichs; M G Bayer; A L Cheung
Journal: J Bacteriol Date: 1996-01 Impact factor: 3.490

7. SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation.

Authors: Y Chien; A C Manna; S J Projan; A L Cheung
Journal: J Biol Chem Date: 1999-12-24 Impact factor: 5.157

Review 8. Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus.

Authors: Ambrose L Cheung; Arnold S Bayer; Gongyi Zhang; Hattie Gresham; Yan-Qiong Xiong
Journal: FEMS Immunol Med Microbiol Date: 2004-01-15

9. Construction of single-copy integration vectors for Staphylococcus aureus.

Authors: C Y Lee; S L Buranen; Z H Ye
Journal: Gene Date: 1991-07-15 Impact factor: 3.688

10. Variation in extracellular protease production among clinical isolates of Staphylococcus aureus due to different levels of expression of the protease repressor sarA.

Authors: Anna Karlsson; Staffan Arvidson
Journal: Infect Immun Date: 2002-08 Impact factor: 3.441

15 in total

1. SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression.

Authors: Ambrose L Cheung; Koren Nishina; Adhar C Manna
Journal: J Bacteriol Date: 2008-01-04 Impact factor: 3.490

2. Regulation of the intercellular adhesin locus regulator (icaR) by SarA, sigmaB, and IcaR in Staphylococcus aureus.

Authors: Nuno Cerca; Jamie L Brooks; Kimberly K Jefferson
Journal: J Bacteriol Date: 2008-07-25 Impact factor: 3.490

3. SarZ promotes the expression of virulence factors and represses biofilm formation by modulating SarA and agr in Staphylococcus aureus.

Authors: Sandeep Tamber; Ambrose L Cheung
Journal: Infect Immun Date: 2008-10-27 Impact factor: 3.441

Role of the distal sarA promoters in SarA expression in Staphylococcus aureus.

1. Characterization of sarR, a modulator of sar expression in Staphylococcus aureus.

2. Characterization of the SarA virulence gene regulator of Staphylococcus aureus.

3. Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci.

4. SarT, a repressor of alpha-hemolysin in Staphylococcus aureus.

Review 5. Autoinduction and signal transduction in the regulation of staphylococcal virulence.

6. Characterization of the sar locus and its interaction with agr in Staphylococcus aureus.

7. SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation.

Review 8. Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus.

9. Construction of single-copy integration vectors for Staphylococcus aureus.

10. Variation in extracellular protease production among clinical isolates of Staphylococcus aureus due to different levels of expression of the protease repressor sarA.

1. SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression.

2. Regulation of the intercellular adhesin locus regulator (icaR) by SarA, sigmaB, and IcaR in Staphylococcus aureus.

3. SarZ promotes the expression of virulence factors and represses biofilm formation by modulating SarA and agr in Staphylococcus aureus.

4. From Staphylococcus aureus gene regulation to its pattern formation.

5. Salicylic acid activates sigma factor B by rsbU-dependent and -independent mechanisms.

6. Staphylococcus aureus CcpA affects virulence determinant production and antibiotic resistance.

7. Regulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and its impact on sigB expression.

8. Expression of the sarA family of genes in different strains of Staphylococcus aureus.

9. Regulation of Staphylococcus aureus immunodominant antigen B (IsaB).

10. Fluorescent reporters for Staphylococcus aureus.