Literature DB >> 18178734

SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression.

Ambrose L Cheung1, Koren Nishina, Adhar C Manna.   

Abstract

The 375-bp sarA open reading frame is driven by three promoters, P1, P3, and P2. Using gel shift and DNase I footprinting assays, we found that SarA binds to two 26-bp sequences and one 31-bp sequence within the P1 and P3 promoters, respectively. Together with the results of transcription analyses, our data indicate that SarA binds to its own promoter to down-regulate sarA expression.

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Year:  2008        PMID： 18178734      PMCID： PMC2258893          DOI： 10.1128/JB.01826-07

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  23 in total

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Authors:  A Manna; A L Cheung
Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

2.  Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci.

Authors:  P M Dunman; E Murphy; S Haney; D Palacios; G Tucker-Kellogg; S Wu; E L Brown; R J Zagursky; D Shlaes; S J Projan
Journal:  J Bacteriol       Date:  2001-12       Impact factor: 3.490

3.  Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus.

Authors:  M Bischoff; J M Entenza; P Giachino
Journal:  J Bacteriol       Date:  2001-09       Impact factor: 3.490

Review 4.  Autoinduction and signal transduction in the regulation of staphylococcal virulence.

Authors:  Richard P Novick
Journal:  Mol Microbiol       Date:  2003-06       Impact factor: 3.501

5.  Sigma(B) activity depends on RsbU in Staphylococcus aureus.

Authors:  P Giachino; S Engelmann; M Bischoff
Journal:  J Bacteriol       Date:  2001-03       Impact factor: 3.490

6.  Crystal structure of the SarR protein from Staphylococcus aureus.

Authors:  Y Liu; A Manna; R Li; W E Martin; R C Murphy; A L Cheung; G Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-29       Impact factor: 11.205

7.  SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation.

Authors:  Y Chien; A C Manna; S J Projan; A L Cheung
Journal:  J Biol Chem       Date:  1999-12-24       Impact factor: 5.157

8.  sigma(B) activity in Staphylococcus aureus is controlled by RsbU and an additional factor(s) during bacterial growth.

Authors:  M Palma; A L Cheung
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

9.  Agr-independent regulation of fibronectin-binding protein(s) by the regulatory locus sar in Staphylococcus aureus.

Authors:  C Wolz; P Pöhlmann-Dietze; A Steinhuber; Y T Chien; A Manna; W van Wamel; A Cheung
Journal:  Mol Microbiol       Date:  2000-04       Impact factor: 3.501

Review 10.  Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus.

Authors:  Ambrose L Cheung; Arnold S Bayer; Gongyi Zhang; Hattie Gresham; Yan-Qiong Xiong
Journal:  FEMS Immunol Med Microbiol       Date:  2004-01-15
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  19 in total

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Journal:  J Bacteriol       Date:  2010-09-24       Impact factor: 3.490

3.  SarZ promotes the expression of virulence factors and represses biofilm formation by modulating SarA and agr in Staphylococcus aureus.

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4.  Role of PknB kinase in antibiotic resistance and virulence in community-acquired methicillin-resistant Staphylococcus aureus strain USA300.

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Journal:  Infect Immun       Date:  2010-06-14       Impact factor: 3.441

Review 5.  Regulation of prokaryotic gene expression by eukaryotic-like enzymes.

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Journal:  Curr Opin Microbiol       Date:  2012-01-03       Impact factor: 7.934

Review 6.  Regulation of Staphylococcus aureus Virulence.

Authors:  Christian Jenul; Alexander R Horswill
Journal:  Microbiol Spectr       Date:  2019-04-05

7.  Activation of sarX by Rbf is required for biofilm formation and icaADBC expression in Staphylococcus aureus.

Authors:  David Cue; Mei G Lei; Chia Y Lee
Journal:  J Bacteriol       Date:  2013-01-25       Impact factor: 3.490

8.  Genome-scale transcriptional profiling in Staphylococcus aureus : bringing order out of chaos.

Authors:  Vijayaraj Nagarajan; Mark S Smeltzer; Mohamed O Elasri
Journal:  FEMS Microbiol Lett       Date:  2009-05-01       Impact factor: 2.742

9.  AraC-Type Regulator Rbf Controls the Staphylococcus epidermidis Biofilm Phenotype by Negatively Regulating the icaADBC Repressor SarR.

Authors:  Sarah E Rowe; Christopher Campbell; Colm Lowry; Sinead T O'Donnell; Michael E Olson; Jill K Lindgren; Elaine M Waters; Paul D Fey; James P O'Gara
Journal:  J Bacteriol       Date:  2016-10-07       Impact factor: 3.490

10.  Control of thioredoxin reductase gene (trxB) transcription by SarA in Staphylococcus aureus.

Authors:  Anand Ballal; Adhar C Manna
Journal:  J Bacteriol       Date:  2010-01       Impact factor: 3.490
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