Literature DB >> 15965493

Repopulation of cancer cells during therapy: an important cause of treatment failure.

John J Kim1, Ian F Tannock.   

Abstract

Radiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during the intervals between treatments and this process of repopulation is an important cause of treatment failure. Strategies developed to overcome repopulation have improved clinical outcomes, and now new strategies to inhibit repopulation are emerging in parallel with advances in the understanding of underlying biological mechanisms.

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Year:  2005        PMID： 15965493     DOI： 10.1038/nrc1650

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  230 in total

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Review 8.  Cancer stem cells and radioresistance.

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10.  Knockdown of Hypoxia-Inducible Factor 1α Improved the Efficacy of Low-Dose Metronomic Chemotherapy of Paclitaxel in Human Colon Cancer Xenografts.

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