Literature DB >> 15963779

Germinal centers still hold secrets.

Ian C M MacLennan1.   

Abstract

There has been recent progress in understanding the mechanism of somatic hypermutation in germinal centers. By contrast, there is more theory than certainty about the way those cells that acquire heightened affinity for antigen are subsequently selected. Wang and Carter (2005) highlight this in the current issue of Immunity in a study of germinal center development in mice with impaired CD19 signaling.

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Year:  2005        PMID： 15963779     DOI： 10.1016/j.immuni.2005.06.002

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  10 in total

1.  B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins.

Authors:  Jannek Hauser; Natalia Sveshnikova; Anders Wallenius; Sanna Baradaran; Juha Saarikettu; Thomas Grundström
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-18       Impact factor: 11.205

2.  Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice.

Authors:  Shin-ichiro Honda; Naoki Kurita; Akitomo Miyamoto; Yukiko Cho; Kenta Usui; Kie Takeshita; Satoru Takahashi; Teruhito Yasui; Hitoshi Kikutani; Taroh Kinoshita; Teizo Fujita; Satoko Tahara-Hanaoka; Kazuko Shibuya; Akira Shibuya
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-19       Impact factor: 11.205

Review 3.  Sinusoidal immunity: macrophages at the lymphohematopoietic interface.

Authors:  Siamon Gordon; Annette Plüddemann; Subhankar Mukhopadhyay
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-12-11       Impact factor: 10.005

4.  IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine.

Authors:  Elodie Mohr; Adam F Cunningham; Kai-Michael Toellner; Saeeda Bobat; Ruth E Coughlan; Roger A Bird; Ian C M MacLennan; Karine Serre
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-20       Impact factor: 11.205

5.  Somatic hypermutation targeting is influenced by location within the immunoglobulin V region.

Authors:  Reuma Magori Cohen; Steven H Kleinstein; Yoram Louzoun
Journal:  Mol Immunol       Date:  2011-05-18       Impact factor: 4.407

6.  Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.

Authors:  Suresh Koduru; Lalit Kumar; Michel J Massaad; Narayanaswamy Ramesh; Séverine Le Bras; Esra Ozcan; Michiko K Oyoshi; Mayumi Kaku; Yuko Fujiwara; Leonor Kremer; Sandra King; Robert Fuhlbrigge; Scott Rodig; Peter Sage; Chris Carman; Pilar Alcaide; Francis W Luscinskas; Raif S Geha
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-30       Impact factor: 11.205

7.  V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment.

Authors:  Thomas MacCarthy; Susan L Kalis; Sergio Roa; Phuong Pham; Myron F Goodman; Matthew D Scharff; Aviv Bergman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-14       Impact factor: 11.205

8.  Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells.

Authors:  Shannon M Anderson; Ashraf Khalil; Mohamed Uduman; Uri Hershberg; Yoram Louzoun; Ann M Haberman; Steven H Kleinstein; Mark J Shlomchik
Journal:  J Immunol       Date:  2009-11-16       Impact factor: 5.422

9.  Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion.

Authors:  Menno C van Zelm; Tomasz Szczepanski; Mirjam van der Burg; Jacques J M van Dongen
Journal:  J Exp Med       Date:  2007-02-20       Impact factor: 14.307

10.  Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.

Authors:  Muhammad Assad Aslam; Mir Farshid Alemdehy; Eliza Mari Kwesi-Maliepaard; Fitriari Izzatunnisa Muhaimin; Marieta Caganova; Iris N Pardieck; Teun van den Brand; Tibor van Welsem; Iris de Rink; Ji-Ying Song; Elzo de Wit; Ramon Arens; Heinz Jacobs; Fred van Leeuwen
Journal:  EMBO Rep       Date:  2021-01-07       Impact factor: 8.807
  10 in total

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