Literature DB >> 159621

Zinc inhibition of calmodulin: a proposed molecular mechanism of zinc action on cellular functions.

G J Brewer, J C Aster, C A Knutsen, W C Kruckeberg.   

Abstract

Calcium stimulates, and zinc inhibits, a wide variety of cell types. In the erythrocyte, we have found calcium and zinc to have antagonist actions in a variety of systems. An important mechanism for calcium effects on cells is activation of calmodulin. Calmodulin is a small ubiquitous protein which, when activated by calcium, has a large array of cellular regulatory functions. We now report that calmodulin function is inhibited by low concentrations of zinc. Zinc inhibition of calmodulin provides a rational molecular mechanism for the diverse cellular inhibitory effects of zinc, as well as for zinc's antagonism of calcium effects.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 159621     DOI： 10.1002/ajh.2830070107

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  19 in total

1.  Mechanism of HIV reverse transcriptase inhibition by zinc: formation of a highly stable enzyme-(primer-template) complex with profoundly diminished catalytic activity.

Authors:  Katherine J Fenstermacher; Jeffrey J DeStefano
Journal:  J Biol Chem       Date:  2011-09-26       Impact factor: 5.157

2.  Antagonism of calcium by zinc in guinea-pig isolated taenia caeci and trachealis muscle.

Authors:  B Sarriá; J Cortijo; M Martí-Cabrera; E Morcillo; J Esplugues
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739

3.  A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn2+ and generating reactive oxygen species.

Authors:  Van Quan Do; Yoon-Seok Seo; Jung-Min Park; Jieun Yu; Men Thi Hoai Duong; Junichi Nakai; Sang-Kyum Kim; Hee-Chul Ahn; Moo-Yeol Lee
Journal:  Arch Toxicol       Date:  2020-10-19       Impact factor: 5.153

4.  Sequential changes in trace metal, metallothionein and calmodulin concentrations in healing skin wounds.

Authors:  A B Lansdown; B Sampson; A Rowe
Journal:  J Anat       Date:  1999-10       Impact factor: 2.610

5.  Total body zinc depletion and its relationship to the development of hyperprolactinemia in chronic renal insufficiency.

Authors:  O Caticha; D Y Norato; M A Tambascia; A Santana; A Stephanou; N J Sarlis
Journal:  J Endocrinol Invest       Date:  1996 Jul-Aug       Impact factor: 4.256

Review 6.  Endocrine interaction between zinc and prolactin. An interpretative review.

Authors:  J Brandão-Neto; G Madureira; B B Mendonça; W Bloise; A V Castro
Journal:  Biol Trace Elem Res       Date:  1995 Aug-Sep       Impact factor: 3.738

7.  The sensitivity to Zn2+ discriminates between typical and atypical mast cells.

Authors:  M Mousli; J P Gies; C Bertrand; F Pelen; C Bronner; Y Landry
Journal:  Agents Actions       Date:  1990-04

Review 8.  A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease.

Authors:  Mark A Lovell
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

9.  Lanthanides are transported by ionophore A23187 and mimic calcium in the histamine secretion process.

Authors:  M Amellal; Y Landry
Journal:  Br J Pharmacol       Date:  1983-10       Impact factor: 8.739

10.  [Effect of zinc deficiency on 3',5'-cyclic-AMP content and parameters of energy metabolism in the rat].

Authors:  H P Roth; M Kirchgessner
Journal:  Z Ernahrungswiss       Date:  1983-06
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.