M Davies1, S Gupta, G Goldspink, M Winslet. 1. University Department of Surgery, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK.
Abstract
OBJECTIVE: The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy. MATERIALS AND METHODS: Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer. RESULTS: The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources. CONCLUSION: Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.
OBJECTIVE: The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy. MATERIALS AND METHODS: Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer. RESULTS: The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources. CONCLUSION: Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.
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