Literature DB >> 15957938

Convergent synthesis of a complex oxime library using chemical domain shuffling.

Shun Su1, Dayle E Acquilano, Jeevanandam Arumugasamy, Aaron B Beeler, Erin L Eastwood, Joshua R Giguere, Ping Lan, Xiaoguang Lei, Geanna K Min, Adam R Yeager, Ya Zhou, James S Panek, John K Snyder, Scott E Schaus, John A Porco.   

Abstract

[reaction: see text] The synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.

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Year:  2005        PMID： 15957938     DOI： 10.1021/ol051023r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.

Authors:  Eamon Comer; Haibo Liu; Adrien Joliton; Alexandre Clabaut; Christopher Johnson; Lakshmi B Akella; Lisa A Marcaurelle
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

2.  Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold.

Authors:  Baudouin Gerard; Jean-Charles Marié; Bhaumik A Pandya; Maurice D Lee; Haibo Liu; Lisa A Marcaurelle
Journal:  J Org Chem       Date:  2011-02-22       Impact factor: 4.354

3.  Metathesis Cascade Strategies (ROM-RCM-CM): A DOS approach to Skeletally Diverse Sultams.

Authors:  Kyu Ok Jeon; Dinesh Rayabarapu; Alan Rolfe; Kelly Volp; Iman Omar; Paul R Hanson
Journal:  Tetrahedron       Date:  2009-06-27       Impact factor: 2.457

4.  Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations.

Authors:  M Paola Castaldi; Dawn M Troast; John A Porco
Journal:  Org Lett       Date:  2009-08-06       Impact factor: 6.005

5.  Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.

Authors:  Lee F Peng; Sun Suk Kim; Sirinya Matchacheep; Xiaoguang Lei; Shun Su; Wenyu Lin; Weerawat Runguphan; Won-Hyeok Choe; Naoya Sakamoto; Masanori Ikeda; Nobuyuki Kato; Aaron B Beeler; John A Porco; Stuart L Schreiber; Raymond T Chung
Journal:  Antimicrob Agents Chemother       Date:  2007-08-06       Impact factor: 5.191

6.  Protected aminooxyprolines for expedited library synthesis: application to Tsg101-directed proline-oxime containing peptides.

Authors:  Fa Liu; Andrew G Stephen; Robert J Fisher; Terrence R Burke
Journal:  Bioorg Med Chem Lett       Date:  2007-12-07       Impact factor: 2.823

7.  A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization.

Authors:  Smitha Kota; Louis Scampavia; Timothy Spicer; Aaron B Beeler; Virginia Takahashi; John K Snyder; John A Porco; Peter Hodder; Arthur Donny Strosberg
Journal:  Assay Drug Dev Technol       Date:  2010-02       Impact factor: 1.738
  7 in total

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