Literature DB >> 17682098

Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.

Lee F Peng1, Sun Suk Kim, Sirinya Matchacheep, Xiaoguang Lei, Shun Su, Wenyu Lin, Weerawat Runguphan, Won-Hyeok Choe, Naoya Sakamoto, Masanori Ikeda, Nobuyuki Kato, Aaron B Beeler, John A Porco, Stuart L Schreiber, Raymond T Chung.   

Abstract

Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 microM). We then synthesized an analog of these compounds with optimized activity.

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Year:  2007        PMID： 17682098      PMCID： PMC2043288          DOI： 10.1128/AAC.00233-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

Review 1.  Target-oriented and diversity-oriented organic synthesis in drug discovery.

Authors:  S L Schreiber
Journal:  Science       Date:  2000-03-17       Impact factor: 47.728

2.  A synthesis strategy yielding skeletally diverse small molecules combinatorially.

Authors:  Martin D Burke; Eric M Berger; Stuart L Schreiber
Journal:  J Am Chem Soc       Date:  2004-11-03       Impact factor: 15.419

3.  From solution-phase to solid-phase enyne metathesis: crossover in the relative performance of two commonly used ruthenium pre-catalysts.

Authors:  Dominic E A Brittain; B Lawrence Gray; Stuart L Schreiber
Journal:  Chemistry       Date:  2005-08-19       Impact factor: 5.236

4.  A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication.

Authors:  Sun Suk Kim; Lee F Peng; Wenyu Lin; Won-Hyeok Choe; Naoya Sakamoto; Nobuyuki Kato; Masanori Ikeda; Stuart L Schreiber; Raymond T Chung
Journal:  Gastroenterology       Date:  2006-10-21       Impact factor: 22.682

5.  Efficient replication of a full-length hepatitis C virus genome, strain O, in cell culture, and development of a luciferase reporter system.

Authors:  Masanori Ikeda; Ken-Ichi Abe; Hiromichi Dansako; Takashi Nakamura; Kazuhito Naka; Nobuyuki Kato
Journal:  Biochem Biophys Res Commun       Date:  2005-04-22       Impact factor: 3.575

6.  Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds.

Authors:  Xiaoguang Lei; Nava Zaarur; Michael Y Sherman; John A Porco
Journal:  J Org Chem       Date:  2005-08-05       Impact factor: 4.354

7.  A library of spirooxindoles based on a stereoselective three-component coupling reaction.

Authors:  Michael M-C Lo; Christopher S Neumann; Satoshi Nagayama; Ethan O Perlstein; Stuart L Schreiber
Journal:  J Am Chem Soc       Date:  2004-12-15       Impact factor: 15.419

8.  Enantioselective addition of terminal alkynes to isolated isoquinoline iminiums.

Authors:  Alexander M Taylor; Stuart L Schreiber
Journal:  Org Lett       Date:  2006-01-05       Impact factor: 6.005

9.  Catalytic asymmetric [3+2] cycloaddition of azomethine ylides. Development of a versatile stepwise, three-component reaction for diversity-oriented synthesis.

Authors:  Chuo Chen; Xiaodong Li; Stuart L Schreiber
Journal:  J Am Chem Soc       Date:  2003-08-27       Impact factor: 15.419

10.  Complete replication of hepatitis C virus in cell culture.

Authors:  Brett D Lindenbach; Matthew J Evans; Andrew J Syder; Benno Wölk; Timothy L Tellinghuisen; Christopher C Liu; Toshiaki Maruyama; Richard O Hynes; Dennis R Burton; Jane A McKeating; Charles M Rice
Journal:  Science       Date:  2005-06-09       Impact factor: 47.728
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  5 in total

1.  Cell-based Assays to Identify Inhibitors of Viral Disease.

Authors:  Neil Green; Robert D Ott; Richard J Isaacs; Hong Fang
Journal:  Expert Opin Drug Discov       Date:  2008-06-01       Impact factor: 6.098

2.  Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication.

Authors:  Akiko Kusano-Kitazume; Naoya Sakamoto; Yukiko Okuno; Yuko Sekine-Osajima; Mina Nakagawa; Sei Kakinuma; Kei Kiyohashi; Sayuri Nitta; Miyako Murakawa; Seishin Azuma; Yuki Nishimura-Sakurai; Masatoshi Hagiwara; Mamoru Watanabe
Journal:  Antimicrob Agents Chemother       Date:  2011-12-27       Impact factor: 5.191

3.  Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

Authors:  Lee F Peng; Esperance A K Schaefer; Nicole Maloof; Andrew Skaff; Andrew Berical; Craig A Belon; Julie A Heck; Wenyu Lin; David N Frick; Todd M Allen; Henry M Miziorko; Stuart L Schreiber; Raymond T Chung
Journal:  J Infect Dis       Date:  2011-08-15       Impact factor: 5.226

4.  Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C.

Authors:  Craig A Belon; David N Frick
Journal:  Future Virol       Date:  2009-05-01       Impact factor: 1.831

5.  Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach.

Authors:  Claire Marie Filone; Erin N Hodges; Brian Honeyman; G Guy Bushkin; Karla Boyd; Andrew Platt; Feng Ni; Kyle Strom; Lisa Hensley; John K Snyder; John H Connor
Journal:  Chem Biol       Date:  2013-03-21
  5 in total

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