| Literature DB >> 15951062 |
Frederik Roelens1, Kevin Huvaere, Willem Dhooge, Marjan Van Cleemput, Frank Comhaire, Denis De Keukeleire.
Abstract
Nine new (+/-)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins have been synthesized from 2,4,6-trimethoxybenzaldehyde via a short, efficient, and regioselective pathway, together with the unsubstituted analogue (+/-)-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarin. The compounds were tested for estrogenic activity using a yeast-based estrogen screen. Weak estrogenicity was determined for seven members of the series.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15951062 DOI： 10.1016/j.ejmech.2005.04.010
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514