OBJECTIVE: To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS). DESIGN: Retrospective case-control study. SETTING: University-based clinic. PATIENT(S): One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls. INTERVENTION(S): Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls. MAIN OUTCOME MEASURE(S): Androgen receptor gene CAG repeat length in both groups. RESULT(S): The mean CAGn was 21.5 repeats in both groups (NS; t-test). Furthermore, when the CAGn lengths were divided into three categories (CAGn < or =18, 19-24, > or =25), the distribution was similar in both groups (NS; chi2 test). However, all five women carrying < or =15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration. CONCLUSION(S): Androgen receptor CAGn is not a major determinant of PCOS. However, it may be a significant modulator of androgen-related diseases in some individuals.
OBJECTIVE: To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS). DESIGN: Retrospective case-control study. SETTING: University-based clinic. PATIENT(S): One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls. INTERVENTION(S): Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls. MAIN OUTCOME MEASURE(S): Androgen receptor gene CAG repeat length in both groups. RESULT(S): The mean CAGn was 21.5 repeats in both groups (NS; t-test). Furthermore, when the CAGn lengths were divided into three categories (CAGn < or =18, 19-24, > or =25), the distribution was similar in both groups (NS; chi2 test). However, all five women carrying < or =15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration. CONCLUSION(S): Androgen receptor CAGn is not a major determinant of PCOS. However, it may be a significant modulator of androgen-related diseases in some individuals.
Authors: Cui Ying Peng; Hui Jun Xie; Zi Fen Guo; Yu Lin Nie; Jun Chen; Jun Mei Zhou; Jie Yin Journal: J Assist Reprod Genet Date: 2014-07-02 Impact factor: 3.412
Authors: Shilpi Dasgupta; Pisapati V S Sirisha; Kudugunti Neelaveni; Kathragadda Anuradha; Alla G Reddy; Kumarasamy Thangaraj; B Mohan Reddy Journal: PLoS One Date: 2010-08-26 Impact factor: 3.240