| Literature DB >> 15950202 |
Ajay Kher1, Kirstan K Meldrum, Meijing Wang, Ben M Tsai, Jeffrey M Pitcher, Daniel R Meldrum.
Abstract
Renal ischemia-reperfusion (I/R) is an important etiopathological mechanism of acute renal failure (ARF). Despite improvements in the treatment of ARF, it is associated with significant morbidity and mortality. I/R injury also occurs during renal transplantation and leads to reduced allograft survival. Sex differences have been found in I/R injury in many different organs including the kidney. Women have half the mortality of men in ARF. In animal models also, females are protected against renal I/R injury. The mechanisms by which sex affects the outcome to renal I/R injury are being actively investigated. This review will examine the evidence for gender differences in renal I/R injury and discuss the probable mechanisms by which sex affects the renal response to I/R injury.Entities:
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Year: 2005 PMID： 15950202 DOI： 10.1016/j.cardiores.2005.05.005
Source DB: PubMed Journal: Cardiovasc Res ISSN： 0008-6363 Impact factor: 10.787