| Literature DB >> 15949506 |
Nicola De Stefano1, Maria L Bartolozzi, Leonello Guidi, Maria L Stromillo, Antonio Federico.
Abstract
Recent MR studies have emphasised the importance of neuronal and axonal damage in multiple sclerosis. In this respect, proton MR spectroscopy (by monitoring levels of N-acetylaspartate, a putative marker of axonal integrity) has been particularly illuminating by showing indirect evidence of neurodegeneration in both lesional and non-lesional brain tissues from the earliest stages of the disease. The importance of these changes to patients' clinical disability argues for the primary role of neuronal pathology in the pathogenesis of the disease.Entities:
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Year: 2005 PMID： 15949506 DOI： 10.1016/j.jns.2005.03.018
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181