OBJECTIVE: To determine the milk-to-plasma (M/P) concentration ratio of rofecoxib in lactating mothers and estimate likely infant exposure. METHODS: Rofecoxib 25 mg was given to six lactating women at weaning. Blood and milk were sampled up to 72 h post-dose for determination of rofecoxib concentrations. M/P ratios were derived from the respective area under the concentration-time curves. The infant 'dose' in milk was estimated and expressed as a percentage of the maternal dose, corrected for weight. RESULTS: The median (range) M/P ratio and infant 'dose' were 0.25 (0.16-0.32) and 2.1% (1.8-3.2%), respectively. CONCLUSIONS: The use of rofecoxib during breastfeeding is unlikely to pose harm to the suckling infant on the basis of low transfer into human milk.
OBJECTIVE: To determine the milk-to-plasma (M/P) concentration ratio of rofecoxib in lactating mothers and estimate likely infant exposure. METHODS:Rofecoxib 25 mg was given to six lactating women at weaning. Blood and milk were sampled up to 72 h post-dose for determination of rofecoxib concentrations. M/P ratios were derived from the respective area under the concentration-time curves. The infant 'dose' in milk was estimated and expressed as a percentage of the maternal dose, corrected for weight. RESULTS: The median (range) M/P ratio and infant 'dose' were 0.25 (0.16-0.32) and 2.1% (1.8-3.2%), respectively. CONCLUSIONS: The use of rofecoxib during breastfeeding is unlikely to pose harm to the suckling infant on the basis of low transfer into human milk.
Authors: Nikolaus A Haas; Robert Nossal; Christoph H Schneider; Martin A G Lewin; Volker Ocker; Martin Holder; Frank Uhlemann Journal: Pediatr Crit Care Med Date: 2003-04 Impact factor: 3.624
Authors: M C Neville; J C Allen; P C Archer; C E Casey; J Seacat; R P Keller; V Lutes; J Rasbach; M Neifert Journal: Am J Clin Nutr Date: 1991-07 Impact factor: 7.045
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Authors: Jessica L Bates; Locke A Karriker; Matthew L Stock; Kelly M Pertzborn; Luke G Baldwin; Larry W Wulf; C J Lee; Chong Wang; Johann F Coetzee Journal: PLoS One Date: 2014-12-01 Impact factor: 3.240