BACKGROUND: An increase of carotid intima-media thickness (CIMT) has been demonstrated to be associated in many studies with the subsequent risk of cardio- and cerebrovascular events, but the threshold level of CIMT for an increased risk at different ages remains uncertain. OBJECTIVES: We aimed at establishing optimal reference limits associated with a definite increased vascular risk in the general population. METHODS: A cohort of 2580 subjects was enrolled in a population-based cross-sectional survey. CIMT was measured on both left and right common carotid arteries, and age-specific, percentile-based reference ranges for CIMT were computed together with the Framingham risk score. RESULTS: A significant, steady increase of CIMT reference ranges was observed within different age strata. CIMT levels were linearly related with an increase of the Framingham risk score, but after age-adjustment only the upper CIMT quintile was associated with a higher Framingham risk score. CONCLUSIONS: Age-specific reference limits provide better estimate of vascular risk in the population and correlation with established risk factors.
BACKGROUND: An increase of carotid intima-media thickness (CIMT) has been demonstrated to be associated in many studies with the subsequent risk of cardio- and cerebrovascular events, but the threshold level of CIMT for an increased risk at different ages remains uncertain. OBJECTIVES: We aimed at establishing optimal reference limits associated with a definite increased vascular risk in the general population. METHODS: A cohort of 2580 subjects was enrolled in a population-based cross-sectional survey. CIMT was measured on both left and right common carotid arteries, and age-specific, percentile-based reference ranges for CIMT were computed together with the Framingham risk score. RESULTS: A significant, steady increase of CIMT reference ranges was observed within different age strata. CIMT levels were linearly related with an increase of the Framingham risk score, but after age-adjustment only the upper CIMT quintile was associated with a higher Framingham risk score. CONCLUSIONS: Age-specific reference limits provide better estimate of vascular risk in the population and correlation with established risk factors.
Authors: Vesna D Garovic; Natasa M Milic; Tracey L Weissgerber; Michelle M Mielke; Kent R Bailey; Brian Lahr; Muthuvel Jayachandran; Wendy M White; Howard N Hodis; Virginia M Miller Journal: Mayo Clin Proc Date: 2017-08-25 Impact factor: 7.616
Authors: Inge C L van den Munckhof; Helen Jones; Maria T E Hopman; Jacqueline de Graaf; Jean Nyakayiru; Bart van Dijk; Thijs M H Eijsvogels; Dick H J Thijssen Journal: Clin Cardiol Date: 2018-05-12 Impact factor: 2.882
Authors: L Breda; D Di Marzio; C Giannini; S Gaspari; M Nozzi; A Scarinci; F Chiarelli; A Mohn Journal: Clin Res Cardiol Date: 2012-08-11 Impact factor: 5.460
Authors: Matthew C Pflederer; Carlin S Long; Brenda Beaty; Edward P Havranek; Philip S Mehler; Angela Keniston; Mori J Krantz Journal: Tex Heart Inst J Date: 2016-04-01
Authors: P-J Touboul; M G Hennerici; S Meairs; H Adams; P Amarenco; N Bornstein; L Csiba; M Desvarieux; S Ebrahim; R Hernandez Hernandez; M Jaff; S Kownator; T Naqvi; P Prati; T Rundek; M Sitzer; U Schminke; J-C Tardif; A Taylor; E Vicaut; K S Woo Journal: Cerebrovasc Dis Date: 2012-11-01 Impact factor: 2.762
Authors: Ra Tuty Kuswardhani; Ketut Gede Wiradharma; Yenny Kandarini; Gde Raka Widiana; Elysanti Dwi Martadiani Journal: Int J Gen Med Date: 2018-12-18