BACKGROUND: This study assessed whether transient ischemic dilation (TID) of the left ventricle is related to ischemic stunning, manifested by stress-induced decrease of left ventricular ejection fraction (LVEF) and worsening of wall motion, by use of dipyridamole-stress and redistribution thallium 201 gated single photon emission computed tomography (SPECT). METHODS AND RESULTS: Ninety-two consecutive patients undergoing dipyridamole Tl-201 gated SPECT were included. Patients with a TID ratio in the highest quartile were defined as having TID. In patients with TID, end-diastolic volume (EDV) and end-systolic volume (ESV) were both significantly greater on dipyridamole-stress images than on redistribution images (P < .001). The degree of enlargement was much greater for ESV than EDV. In patients without TID, EDV and ESV were both decreased after stress (P < .001). Patients with TID had a lower mean LVEF on dipyridamole-stress images than on redistribution images (P < .001). Patients without TID had a higher mean LVEF on dipyridamole-stress images than on redistribution images (P < .001). Patients with TID had a significant worsening of global wall motion on dipyridamole-stress images than on redistribution images (P < .001), but patients without TID did not. CONCLUSION: TID was significantly correlated with ischemic stunning, and the enlargement of ESV was an important factor resulting in TID.
BACKGROUND: This study assessed whether transient ischemic dilation (TID) of the left ventricle is related to ischemic stunning, manifested by stress-induced decrease of left ventricular ejection fraction (LVEF) and worsening of wall motion, by use of dipyridamole-stress and redistribution thallium 201 gated single photon emission computed tomography (SPECT). METHODS AND RESULTS: Ninety-two consecutive patients undergoing dipyridamole Tl-201 gated SPECT were included. Patients with a TID ratio in the highest quartile were defined as having TID. In patients with TID, end-diastolic volume (EDV) and end-systolic volume (ESV) were both significantly greater on dipyridamole-stress images than on redistribution images (P < .001). The degree of enlargement was much greater for ESV than EDV. In patients without TID, EDV and ESV were both decreased after stress (P < .001). Patients with TID had a lower mean LVEF on dipyridamole-stress images than on redistribution images (P < .001). Patients without TID had a higher mean LVEF on dipyridamole-stress images than on redistribution images (P < .001). Patients with TID had a significant worsening of global wall motion on dipyridamole-stress images than on redistribution images (P < .001), but patients without TID did not. CONCLUSION: TID was significantly correlated with ischemic stunning, and the enlargement of ESV was an important factor resulting in TID.
Authors: C Bacher-Stier; S Müller; O Pachinger; S Strolz; H Erler; R Moncayo; M Wenger; E Donnemiller; G Riccabona Journal: Eur J Nucl Med Date: 1999-12
Authors: Jonas Francisco Y Santiago; Sherif I Heiba; Suman Jana; Majid Mirzaitehrane; Fuat Dede; Hussein M Abdel-Dayem Journal: Eur J Nucl Med Mol Imaging Date: 2002-05-17 Impact factor: 9.236
Authors: A T Weiss; D S Berman; A S Lew; J Nielsen; B Potkin; H J Swan; A Waxman; J Maddahi Journal: J Am Coll Cardiol Date: 1987-04 Impact factor: 24.094
Authors: Mohamed A Mandour Ali; Jamieson M Bourque; Adel H Allam; George A Beller; Denny D Watson Journal: J Nucl Cardiol Date: 2011-09-23 Impact factor: 5.952
Authors: Guido Germano; Paul B Kavanagh; Piotr J Slomka; Serge D Van Kriekinge; Geoff Pollard; Daniel S Berman Journal: J Nucl Cardiol Date: 2007-07 Impact factor: 5.952