AIMS: The aim of our study was to analyse the level of circulating interleukin-10 (IL-10) and relate it to the grade of albuminuria in patients with diabetic nephropathy (DN) due to type 1 diabetes mellitus (DM). Since IL-10 has met the criteria for an anti-inflammatory and an immunosuppressive cytokine, its activity may be important for clinical outcome of DN. METHODS: The IL-10 level was measured by ELISA in serum samples from thirty patients with DN due to type 1 DM, and compared with thirty patients with type 1 DM without DN and a control group of thirty, healthy, age- and sex-matched people. RESULTS: We observed a greatly elevated concentration of circulating IL-10 in 30/30 DM patients with DN (mean 140 pg/mL +/- 102), compared to DM patients without DN in whom IL-10 was detectable in only 11/30 patients (0.79 pg/mL +/- 1.24), and the group of healthy people in whom IL-10 was detectable in only 3/30 donors (0.92 pg/mL +/- 0.17). IL-10 appeared to be the strongest independent predictor of albuminuria, followed by HbA1c, diastolic blood pressure and DN duration. There was a positive correlation between the values of IL-10 and albuminuria in DM patients with DN. The patients in the fourth quartile of albuminuria had a distinctly higher concentration of IL-10 than those in the lower quartiles. CONCLUSIONS: The increased concentration of IL-10 in the serum samples from DM patients with DN seems to depend on the severity of the nephropathy. The excessive IL-10 production may indirectly contribute towards DN progression. On the other hand, it may explain the relatively long course of diabetic nephropathy.
AIMS: The aim of our study was to analyse the level of circulating interleukin-10 (IL-10) and relate it to the grade of albuminuria in patients with diabetic nephropathy (DN) due to type 1 diabetes mellitus (DM). Since IL-10 has met the criteria for an anti-inflammatory and an immunosuppressive cytokine, its activity may be important for clinical outcome of DN. METHODS: The IL-10 level was measured by ELISA in serum samples from thirty patients with DN due to type 1 DM, and compared with thirty patients with type 1 DM without DN and a control group of thirty, healthy, age- and sex-matched people. RESULTS: We observed a greatly elevated concentration of circulating IL-10 in 30/30 DMpatients with DN (mean 140 pg/mL +/- 102), compared to DMpatients without DN in whom IL-10 was detectable in only 11/30 patients (0.79 pg/mL +/- 1.24), and the group of healthy people in whom IL-10 was detectable in only 3/30 donors (0.92 pg/mL +/- 0.17). IL-10 appeared to be the strongest independent predictor of albuminuria, followed by HbA1c, diastolic blood pressure and DN duration. There was a positive correlation between the values of IL-10 and albuminuria in DMpatients with DN. The patients in the fourth quartile of albuminuria had a distinctly higher concentration of IL-10 than those in the lower quartiles. CONCLUSIONS: The increased concentration of IL-10 in the serum samples from DMpatients with DN seems to depend on the severity of the nephropathy. The excessive IL-10 production may indirectly contribute towards DN progression. On the other hand, it may explain the relatively long course of diabetic nephropathy.
Authors: Rodrigo M C Pestana; Caroline P Domingueti; Rita C F Duarte; Rodrigo B Fóscolo; Janice S Reis; Ana Maria S Rodrigues; Laís B Martins; Lirlândia P Sousa; Daniela P Lage; Cláudia N Ferreira; Adaliene V M Ferreira; Ana P Fernandes; Karina B Gomes Journal: Immunol Res Date: 2016-08 Impact factor: 2.829
Authors: Thomas W McDade; Paula S Tallman; Linda S Adair; Judith Borja; Christopher W Kuzawa Journal: Am J Phys Anthropol Date: 2011-08-24 Impact factor: 2.868
Authors: Luz E Chavarria-Buenrostro; Jorge Hernandez-Bello; Jose F Muñoz-Valle; Jose Macias-Barragan; Liliana B Hernandez-Carrillo; Jorge F Topete-Reyes; Renato Parra-Michel; Maria G Ramirez-Dueñas; Pedro E Sanchez-Hernandez; Ana L Pereira-Suarez; Eden Oceguera-Contreras; Margarita Montoya-Buelna Journal: J Clin Lab Anal Date: 2018-10-21 Impact factor: 2.352