Literature DB >> 15940738

Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C.

Sofia Barluenga1, Emilie Moulin, Pilar Lopez, Nicolas Winssinger.   

Abstract

A modular synthesis for pochonin C and radicicol is reported. The two natural products were prepared in seven and eight steps, respectively, from three readily available fragments. Alternative syntheses of these compounds were achieved using a combination of polymer-bound reagents and solid phase reactions. The conformation of the two natural products was studied and compared by using 2D NMR spectroscopy.

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Year:  2005        PMID： 15940738     DOI： 10.1002/chem.200500160

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  7 in total

1.  Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor.

Authors:  Sofia Barluenga; Cuihua Wang; Jean-Gonzague Fontaine; Kaïss Aouadi; Kristin Beebe; Shinji Tsutsumi; Len Neckers; Nicolas Winssinger
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

2.  Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation.

Authors:  Yiyang Luo; Xianglin Yin; Mingji Dai
Journal:  J Antibiot (Tokyo)       Date:  2019-02-13       Impact factor: 2.649

3.  Large-scale total synthesis of 13C3-labeled citrinin and its metabolite dihydrocitrinone.

Authors:  Dominik Bergmann; Florian Hübner; Birgit Wibbeling; Constantin Daniliuc; Benedikt Cramer; Hans-Ulrich Humpf
Journal:  Mycotoxin Res       Date:  2018-02-13       Impact factor: 3.833

Review 4.  Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?

Authors:  Anuj Khandelwal; Vincent M Crowley; Brian S J Blagg
Journal:  Med Res Rev       Date:  2015-05-25       Impact factor: 12.944

Review 5.  Natural product inhibitors of Hsp90: potential leads for drug discovery.

Authors:  M W Amolins; B S J Blagg
Journal:  Mini Rev Med Chem       Date:  2009-02       Impact factor: 3.862

Review 6.  Natural and Synthetic Lactones Possessing Antitumor Activities.

Authors:  Younghoon Kim; Sandip Sengupta; Taebo Sim
Journal:  Int J Mol Sci       Date:  2021-01-21       Impact factor: 6.208

7.  Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells.

Authors:  Eric J Mejia; Steven T Loveridge; George Stepan; Angela Tsai; Gregg S Jones; Tiffany Barnes; Kimberly N White; Marija Drašković; Karen Tenney; Manuel Tsiang; Romas Geleziunas; Tomas Cihlar; Nikos Pagratis; Yang Tian; Helen Yu; Phillip Crews
Journal:  J Nat Prod       Date:  2014-02-04       Impact factor: 4.050
  7 in total

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