Literature DB >> 15939757

Surface envelope glycoprotein is B-lymphocyte immunodominant in sheep naturally infected with ovine progressive pneumonia virus.

Lynn M Herrmann1, Travis C McGuire, Isidro Hötzel, Gregory S Lewis, Donald P Knowles.   

Abstract

The B-lymphocyte-immunodominant antigen involved in naturally ovine progressive pneumonia virus (OPPV)-infected mature sheep remains unknown. Therefore, the amount of antibody in sera from 10 naturally OPPV-infected sheep was evaluated by immunoprecipitation (IP) of the major viral proteins in [(35)S]methionine/cysteine-labeled OPPV (whole virus) lysate. Using an excess of OPPV proteins in whole-virus lysate, 8 out of 10 sheep had the highest serum antibody IP endpoint titers to the gp135 surface envelope glycoprotein (SU). Also, 2 out of 10 sheep had equivalent serum antibody IP endpoint titers to the transmembrane glycoprotein oligomer (TM90) and SU. Since these data indicate that SU is the immunodominant protein in most mature sheep persistently infected with OPPV, SU-specific diagnostic serological assays can be utilized for OPPV diagnosis.

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Year:  2005        PMID： 15939757      PMCID： PMC1151977          DOI： 10.1128/CDLI.12.6.797-800.2005

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  10 in total

1.  Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive pneumonia viruses involves all virion-associated proteins and glycoproteins.

Authors:  R P Gogolewski; D S Adams; T C McGuire; K L Banks; W P Cheevers
Journal:  J Gen Virol       Date:  1985-06       Impact factor: 3.891

2.  Monoclonal antibodies to conformational epitopes of the surface glycoprotein of caprine arthritis-encephalitis virus: potential application to competitive-inhibition enzyme-linked immunosorbent assay for detecting antibodies in goat sera.

Authors:  F Ozyörük; W P Cheevers; G A Hullinger; T C McGuire; M Hutton; D P Knowles
Journal:  Clin Diagn Lab Immunol       Date:  2001-01

3.  Variability and immunogenicity of caprine arthritis-encephalitis virus surface glycoprotein.

Authors:  S Valas; C Benoit; C Baudry; G Perrin; R Z Mamoun
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

4.  Immunoblot analysis of the antibody response to ovine lentivirus infections.

Authors:  D J Houwers; I M Nauta
Journal:  Vet Microbiol       Date:  1989-02       Impact factor: 3.293

5.  B-cell epitopes of the envelope glycoprotein of caprine arthritis-encephalitis virus and antibody response in infected goats.

Authors:  Giuseppe Bertoni; Christian Hertig; Marie-Luise Zahno; Hans-Rudolf Vogt; Sophie Dufour; Pablo Cordano; Ernst Peterhans; William P Cheevers; Pierre Sonigo; Gianfranco Pancino
Journal:  J Gen Virol       Date:  2000-12       Impact factor: 3.891

6.  Detection of serum antibodies to ovine progressive pneumonia virus in sheep by using a caprine arthritis-encephalitis virus competitive-inhibition enzyme-linked immunosorbent assay.

Authors:  Lynn M Herrmann; William P Cheevers; Katherine L Marshall; Travis C McGuire; Melinda M Hutton; Gregory S Lewis; Donald P Knowles
Journal:  Clin Diagn Lab Immunol       Date:  2003-09

7.  Antibody reactivity to the immunodominant epitopes of the caprine arthritis-encephalitis virus gp38 transmembrane protein associates with the development of arthritis.

Authors:  G Bertoni; M L Zahno; R Zanoni; H R Vogt; E Peterhans; G Ruff; W P Cheevers; P Sonigo; G Pancino
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103

8.  Severity of arthritis is predicted by antibody response to gp135 in chronic infection with caprine arthritis-encephalitis virus.

Authors:  D Knowles; W Cheevers; T McGuire; T Stem; J Gorham
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

9.  Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis.

Authors:  T C McGuire; D P Knowles; W C Davis; A L Brassfield; T A Stem; W P Cheevers
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

10.  Preferential immune response to virion surface glycoproteins by caprine arthritis-encephalitis virus-infected goats.

Authors:  G C Johnson; A F Barbet; P Klevjer-Anderson; T C McGuire
Journal:  Infect Immun       Date:  1983-08       Impact factor: 3.441
  10 in total
  3 in total

1.  Analysis of the antibody response to an immunodominant epitope of the envelope glycoprotein of a lentivirus and its diagnostic potential.

Authors:  Franca Mordasini; Hans-Rudolf Vogt; Marie-Luise Zahno; Ariane Maeschli; Chiara Nenci; Reto Zanoni; Ernst Peterhans; Giuseppe Bertoni
Journal:  J Clin Microbiol       Date:  2006-03       Impact factor: 5.948

2.  Small-ruminant lentivirus enhances PrPSc accumulation in cultured sheep microglial cells.

Authors:  James B Stanton; Donald P Knowles; Katherine I O'Rourke; Lynn M Herrmann-Hoesing; Bruce A Mathison; Timothy V Baszler
Journal:  J Virol       Date:  2008-08-06       Impact factor: 5.103

3.  Peripheral ovine progressive pneumonia provirus levels correlate with and predict histological tissue lesion severity in naturally infected sheep.

Authors:  Lynn M Herrmann-Hoesing; Susan M Noh; Stephen N White; Kevin R Snekvik; Thomas Truscott; Donald P Knowles
Journal:  Clin Vaccine Immunol       Date:  2009-03-04
  3 in total

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