| Literature DB >> 15936513 |
Wadad Hassoun1, Stephane Thobois, Nathalie Ginovart, Luis Garcia-Larrea, Marion Le Cavorsin, Stephane Guillouet, Frederic Bonnefoi, Nicolas Costes, Frank Lavenne, Jean Pierre Martin, Emmanuel Broussolle, Vincent Leviel.
Abstract
Sensory stimulations of the forelimb in cats are known to increase dopamine release in the ipsilateral striatum and to decrease it in the homologous contralateral structure. Using positron emission tomography in both humans and cats, the present study shows that such sensory stimulations greatly reduce [(18)F]FDOPA accumulation ipsilateral to the stimulation (by 40.4% and 26.4% in the human caudate and putamen, respectively, and by 33.3% in the cat striatum). This decrease in striatal [(18)F]FDOPA uptake suggests a reduced DA storage resulting from the increased amine release. No change was observed in the contralateral striatum in neither human or cat suggesting, in contrast, that [(18)F]FDOPA accumulation is not facilitated by decreased DA release. These results support the hypothesis that sensory stimulations activate a non-synaptic mode of dopamine release.Entities:
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Year: 2005 PMID： 15936513 DOI： 10.1016/j.neulet.2005.03.067
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046