Literature DB >> 15932944

Survival adjustment of mature dendritic cells by IL-15.

Sigrid P Dubois1, Thomas A Waldmann, Jürgen R Müller.   

Abstract

The survival of CD8+/CD44(hi) memory phenotype T cells depends on an IL-15 activity on nonlymphoid cells. Here, we report that IL-15 and its receptor were induced on dendritic cells (DCs) by a combination of IFN-gamma and NF-kappaB relA inducers. IL-15 conferred in an autocrine loop resistance to apoptosis that accompanied the maturation process in DCs in vitro. As an apparent result in vivo, mice deficient in IL-15 or its receptor harbor few DCs. Injecting DCs into IL-15-/- mice was associated with the appearance of CD8+/CD44(hi) T cells that depended on IL-15 expression but also correlated with the longevity of the DCs. These findings support the hypothesis that DCs mediate the effect of IL-15 on CD8+/CD44(hi) memory phenotype T cells.

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Year:  2005        PMID： 15932944      PMCID： PMC1150852          DOI： 10.1073/pnas.0503360102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

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Authors:  G G Neely; S M Robbins; E K Amankwah; S Epelman; H Wong; J C Spurrell; K K Jandu; W Zhu; D K Fogg; C B Brown; C H Mody
Journal:  J Immunol       Date:  2001-11-01       Impact factor: 5.422

2.  Mature dendritic cells are protected from Fas/CD95-mediated apoptosis by upregulation of Bcl-X(L).

Authors:  Andreas Lundqvist; Takako Nagata; Rolf Kiessling; Pavel Pisa
Journal:  Cancer Immunol Immunother       Date:  2002-03-01       Impact factor: 6.968

3.  A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells.

Authors:  Wu-Shiun Hou; Luk Van Parijs
Journal:  Nat Immunol       Date:  2004-05-09       Impact factor: 25.606

Review 4.  Memory CD8 T-cell differentiation during viral infection.

Authors:  E John Wherry; Rafi Ahmed
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

5.  Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3'-OH kinase pathway.

Authors:  Yunji Park; Seung Woo Lee; Young Chul Sung
Journal:  J Immunol       Date:  2002-01-01       Impact factor: 5.422

6.  Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells.

Authors:  Kimberly S Schluns; Kristina Williams; Averil Ma; Xin X Zheng; Leo Lefrançois
Journal:  J Immunol       Date:  2002-05-15       Impact factor: 5.422

7.  IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter.

Authors:  Jennifer M Mariner; Yael Mamane; John Hiscott; Thomas A Waldmann; Nazli Azimi
Journal:  J Immunol       Date:  2002-06-01       Impact factor: 5.422

8.  Bcl-2 controls dendritic cell longevity in vivo.

Authors:  Adam Nopora; Thomas Brocker
Journal:  J Immunol       Date:  2002-09-15       Impact factor: 5.422

9.  Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice.

Authors:  Rima Koka; Patrick R Burkett; Marcia Chien; Sophia Chai; Faye Chan; James P Lodolce; David L Boone; Averil Ma
Journal:  J Exp Med       Date:  2003-04-14       Impact factor: 14.307

10.  Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells.

Authors:  Todd C Becker; E John Wherry; David Boone; Kaja Murali-Krishna; Rustom Antia; Averil Ma; Rafi Ahmed
Journal:  J Exp Med       Date:  2002-06-17       Impact factor: 14.307
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  39 in total

1.  Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques.

Authors:  Maren Q DeGottardi; Afam A Okoye; Mukta Vaidya; Aarthi Talla; Audrie L Konfe; Matthew D Reyes; Joseph A Clock; Derick M Duell; Alfred W Legasse; Amit Sabnis; Byung S Park; Michael K Axthelm; Jacob D Estes; Keith A Reiman; Rafick-Pierre Sekaly; Louis J Picker
Journal:  J Immunol       Date:  2016-07-18       Impact factor: 5.422

2.  Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.

Authors:  Meili Zhang; Wei Ju; Zhengsheng Yao; Ping Yu; Bih-Rong Wei; R Mark Simpson; Rebecca Waitz; Marcella Fassò; James P Allison; Thomas A Waldmann
Journal:  J Immunol       Date:  2012-05-16       Impact factor: 5.422

Review 3.  The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.

Authors:  Pin-Yu Perera; Jack H Lichy; Thomas A Waldmann; Liyanage P Perera
Journal:  Microbes Infect       Date:  2011-10-25       Impact factor: 2.700

4.  ITK and IL-15 support two distinct subsets of CD8+ T cells.

Authors:  Sigrid Dubois; Thomas A Waldmann; Jürgen R Müller
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-31       Impact factor: 11.205

5.  Selective dependence of H2-M3-restricted CD8 responses on IL-15.

Authors:  Jürgen R Müller; Thomas A Waldmann; Sigrid Dubois
Journal:  J Immunol       Date:  2012-02-06       Impact factor: 5.422

6.  The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells.

Authors:  Noriko Sato; Hiral J Patel; Thomas A Waldmann; Yutaka Tagaya
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-03       Impact factor: 11.205

7.  Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice.

Authors:  Qing Zhu; Colt Egelston; Susan Gagnon; Yongjun Sui; Igor M Belyakov; Dennis M Klinman; Jay A Berzofsky
Journal:  J Clin Invest       Date:  2010-01-25       Impact factor: 14.808

8.  Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage.

Authors:  Takashi Kawasaki; Mashkoor A Choudhry; Martin G Schwacha; Kirby I Bland; Irshad H Chaudry
Journal:  Am J Physiol Cell Physiol       Date:  2008-11-05       Impact factor: 4.249

9.  IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection.

Authors:  Jodi McGill; Nico Van Rooijen; Kevin L Legge
Journal:  J Exp Med       Date:  2010-03-08       Impact factor: 14.307

10.  Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.

Authors:  Jürgen R Müller; Thomas A Waldmann; Michael J Kruhlak; Sigrid Dubois
Journal:  J Biol Chem       Date:  2012-10-16       Impact factor: 5.157
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