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Literature DB >> 15928941

[Growth hormone therapy in adults].

Abstract

In adult patients with growth hormone deficiency due to organic hypopituitarism, substitution with growth hormone is very useful and well established. Positive influence on numerous target parameters has been investigated in randomised controlled trials (evidence level I) and could be documented. Thus, growth hormone substitution in hypopituitarism is scientifically founded and has been admitted by the authorities in the European Union. Concerning pharmacotherapy with growth hormone in healthy elderly persons without pituitary disease and also doping in sports, the situation is completely different. Use of growth hormone in these circumstances has not sufficiently been investigated concerning indications, efficacy and safety. Ethical and economical aspects have not been evaluated yet. Serious concerns about the therapeutic safety need to be considered.

Entities: Disease Gene Species

Mesh：

Substances：
Human Growth Hormone

Year: 2005 PMID： 15928941 DOI： 10.1007/s00108-005-1426-5

Source DB: PubMed Journal: Internist (Berl) ISSN： 0020-9554 Impact factor: 0.743

13 in total

1. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society.

Authors:
Journal: J Clin Endocrinol Metab Date: 2000-11 Impact factor: 5.958

2. Growth hormone administration and exercise effects on muscle fiber type and diameter in moderately frail older people.

Authors: J V Hennessey; J A Chromiak; S DellaVentura; S E Reinert; J Puhl; D P Kiel; C J Rosen; H Vandenburgh; D B MacLean
Journal: J Am Geriatr Soc Date: 2001-07 Impact factor: 5.562

3. Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men.

Authors: T Münzer; S M Harman; P Hees; E Shapiro; C Christmas; M F Bellantoni; T E Stevens; K G O'Connor; K M Pabst; C St Clair; J D Sorkin; M R Blackman
Journal: J Clin Endocrinol Metab Date: 2001-08 Impact factor: 5.958

Review 4. IGF-1 signaling and aging.

Authors: Martin Holzenberger; Laurent Kappeler; Carlos De Magalhaes Filho
Journal: Exp Gerontol Date: 2004 Nov-Dec Impact factor: 4.032

5. Critical evaluation of the safety of recombinant human growth hormone administration: statement from the Growth Hormone Research Society.

Authors:
Journal: J Clin Endocrinol Metab Date: 2001-05 Impact factor: 5.958

6. Effects of human growth hormone in men over 60 years old.

Authors: D Rudman; A G Feller; H S Nagraj; G A Gergans; P Y Lalitha; A F Goldberg; R A Schlenker; L Cohn; I W Rudman; D E Mattson
Journal: N Engl J Med Date: 1990-07-05 Impact factor: 91.245

7. Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study.

Authors: Georg Brabant; Alexander von zur Mühlen; Christian Wüster; Michael B Ranke; Jürgen Kratzsch; Wieland Kiess; Jean-Marie Ketelslegers; Lars Wilhelmsen; Lena Hulthén; Bernhard Saller; Anders Mattsson; Jürgen Wilde; Rudolf Schemer; Peter Kann
Journal: Horm Res Date: 2003

8. Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction.

Authors: Isao Shimokawa; Yoshikazu Higami; Tomoshi Tsuchiya; Hiroshi Otani; Toshimitsu Komatsu; Takuya Chiba; Haruyoshi Yamaza
Journal: FASEB J Date: 2003-04-08 Impact factor: 5.191

[Growth hormone therapy in adults].

1. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society.

2. Growth hormone administration and exercise effects on muscle fiber type and diameter in moderately frail older people.

3. Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men.

Review 4. IGF-1 signaling and aging.

5. Critical evaluation of the safety of recombinant human growth hormone administration: statement from the Growth Hormone Research Society.

6. Effects of human growth hormone in men over 60 years old.

7. Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study.

8. Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction.

9. Growth hormone replacement in healthy older men improves body composition but not functional ability.

10. Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice.

1. Interdental spacing and orthodontic treatment in competitive athletes: clues to doping with growth hormones?

Review 2. [Growth hormone therapy in adult patients: a review].