Literature DB >> 15928926

Polypeptide chain termination and stop codon readthrough on eukaryotic ribosomes.

S Rospert1, M Rakwalska, Y Dubaquié.   

Abstract

During protein translation, a variety of quality control checks ensure that the resulting polypeptides deviate minimally from their genetic encoding template. Translational fidelity is central in order to preserve the function and integrity of each cell. Correct termination is an important aspect of translational fidelity, and a multitude of mechanisms and players participate in this exquisitely regulated process. This review explores our current understanding of eukaryotic termination by highlighting the roles of the different ribosomal components as well as termination factors and ribosome-associated proteins, such as chaperones.

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Year:  2005        PMID： 15928926     DOI： 10.1007/3-540-28217-3_1

Source DB:  PubMed          Journal:  Rev Physiol Biochem Pharmacol        ISSN： 0303-4240            Impact factor:   5.545


  16 in total

1.  Release factor eRF3 mediates premature translation termination on polylysine-stalled ribosomes in Saccharomyces cerevisiae.

Authors:  Marco Chiabudini; Arlette Tais; Ying Zhang; Sachiko Hayashi; Tina Wölfle; Edith Fitzke; Sabine Rospert
Journal:  Mol Cell Biol       Date:  2014-08-25       Impact factor: 4.272

2.  Fine-tuning of translation termination efficiency in Saccharomyces cerevisiae involves two factors in close proximity to the exit tunnel of the ribosome.

Authors:  Isabelle Hatin; Céline Fabret; Olivier Namy; Wayne A Decatur; Jean-Pierre Rousset
Journal:  Genetics       Date:  2007-05-04       Impact factor: 4.562

3.  Readthrough of nonsense mutation W822X in the SCN5A gene can effectively restore expression of cardiac Na+ channels.

Authors:  Siyong Teng; Lizhi Gao; Vesa Paajanen; Jielin Pu; Zheng Fan
Journal:  Cardiovasc Res       Date:  2009-04-17       Impact factor: 10.787

4.  Translational readthrough of GLA nonsense mutations suggests dominant-negative effects exerted by the interaction of wild-type and missense variants.

Authors:  Silvia Lombardi; Mattia Ferrarese; Saverio Marchi; Paolo Pinton; Mirko Pinotti; Francesco Bernardi; Alessio Branchini
Journal:  RNA Biol       Date:  2019-10-15       Impact factor: 4.652

Review 5.  Two chaperones locked in an embrace: structure and function of the ribosome-associated complex RAC.

Authors:  Ying Zhang; Irmgard Sinning; Sabine Rospert
Journal:  Nat Struct Mol Biol       Date:  2017-08-03       Impact factor: 15.369

6.  Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.

Authors:  Christoph Leidig; Gert Bange; Jürgen Kopp; Stefan Amlacher; Ajay Aravind; Stephan Wickles; Gregor Witte; Ed Hurt; Roland Beckmann; Irmgard Sinning
Journal:  Nat Struct Mol Biol       Date:  2012-12-02       Impact factor: 15.369

7.  The chaperone network connected to human ribosome-associated complex.

Authors:  Himjyot Jaiswal; Charlotte Conz; Hendrik Otto; Tina Wölfle; Edith Fitzke; Matthias P Mayer; Sabine Rospert
Journal:  Mol Cell Biol       Date:  2011-01-18       Impact factor: 4.272

8.  Ribosome-associated complex binds to ribosomes in close proximity of Rpl31 at the exit of the polypeptide tunnel in yeast.

Authors:  Kristin Peisker; Daniel Braun; Tina Wölfle; Jendrik Hentschel; Ursula Fünfschilling; Gunter Fischer; Albert Sickmann; Sabine Rospert
Journal:  Mol Biol Cell       Date:  2008-10-01       Impact factor: 4.138

9.  Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1.

Authors:  Leo E Wong; Yan Li; Shubhadra Pillay; Ludmila Frolova; Konstantin Pervushin
Journal:  Nucleic Acids Res       Date:  2012-03-01       Impact factor: 16.971

10.  Bacterial phylogenetic tree construction based on genomic translation stop signals.

Authors:  Lijing Xu; Jimmy Kuo; Jong-Kang Liu; Tit-Yee Wong
Journal:  Microb Inform Exp       Date:  2012-05-31
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