STUDY DESIGN: Porcine and human cervical spine specimens were in vitro biomechanically compared with different instrumentation techniques. OBJECTIVES: To evaluate whether subaxial porcine cervical spines are a valid model for implant testing in a single level corpectomy. SUMMARY OF BACKGROUND DATA: Biomechanical in vitro tests are widely used for implant tests, mainly with human spine specimens. The availability of human cadavers is limited and the properties of the specimen regarding age, bone mineral density, and grade of degenerative changes is inhomogeneous. METHODS: Six porcine and six human cervical specimens were loaded nondestructively with pure moments: 1) in an intact state; 2) after a corpectomy of C5 and substitution by a cage with integrated force sensor; 3) after additional instrumentation with a posterior screw and rod system with: a) lateral mass and b) pedicle screws; 4) after instrumentation with an anterior plate; and 5) with a circumferential instrumentation. The unconstrained motion and the axial loads occurring in the corpectomy gap were measured, as well as the bone mineral density of the specimen before testing. RESULTS: The range of motion in the intact state, as well as for the different instrumentations, was comparable for flexion-extension. In lateral bending and axial rotation, marked differences in the intact state as well as for pedicle screw instrumentations occurred. CONCLUSIONS: The subaxial porcine cervical spine is a potential model in flexion-extension because of its biomechanical similarity. For lateral bending and axial rotation, the marked differences severly restrict the comparability.
STUDY DESIGN: Porcine and human cervical spine specimens were in vitro biomechanically compared with different instrumentation techniques. OBJECTIVES: To evaluate whether subaxial porcine cervical spines are a valid model for implant testing in a single level corpectomy. SUMMARY OF BACKGROUND DATA: Biomechanical in vitro tests are widely used for implant tests, mainly with human spine specimens. The availability of human cadavers is limited and the properties of the specimen regarding age, bone mineral density, and grade of degenerative changes is inhomogeneous. METHODS: Six porcine and six human cervical specimens were loaded nondestructively with pure moments: 1) in an intact state; 2) after a corpectomy of C5 and substitution by a cage with integrated force sensor; 3) after additional instrumentation with a posterior screw and rod system with: a) lateral mass and b) pedicle screws; 4) after instrumentation with an anterior plate; and 5) with a circumferential instrumentation. The unconstrained motion and the axial loads occurring in the corpectomy gap were measured, as well as the bone mineral density of the specimen before testing. RESULTS: The range of motion in the intact state, as well as for the different instrumentations, was comparable for flexion-extension. In lateral bending and axial rotation, marked differences in the intact state as well as for pedicle screw instrumentations occurred. CONCLUSIONS: The subaxial porcine cervical spine is a potential model in flexion-extension because of its biomechanical similarity. For lateral bending and axial rotation, the marked differences severly restrict the comparability.