| Literature DB >> 15925362 |
Akiko Takaoka1, Iwao Arai, Masanori Sugimoto, Akie Yamaguchi, Makoto Tanaka, Shiro Nakaike.
Abstract
To search for the pruritogen of atopic dermatitis, a characteristic symptom in atopic dermatitis patients, we examined interleukin-31 (IL-31) mRNA expression in NC/Nga mice as an animal model of atopic dermatitis. The expression of IL-31 mRNA in the skin of NC/Nga mice with scratching behavior was significantly higher than that in NC/Nga mice without scratching behavior. Our findings suggest that IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis.Entities:
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Year: 2005 PMID： 15925362 DOI： 10.1016/j.ejphar.2005.04.040
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432