| Literature DB >> 21262749 |
Randeep S Jawa1, Sergio Anillo, Kristin Huntoon, Heinz Baumann, Mahmoud Kulaylat.
Abstract
A variety of cytokines play a role in the response to an inflammatory stimulus. The interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus. They act locally and systemically to generate a variety of physiologic responses, principal among them is the acute phase response. The IL-6 type cytokines demonstrate pleiotropy and redundancy of actions. This is made possible by the distinctive characteristics of the IL-6 receptor complex, which contains an ubiquitous subunit that is shared by most IL-6-type cytokines, as well as a cytokine-specific subunit.Entities:
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Year: 2011 PMID: 21262749 PMCID: PMC6209321 DOI: 10.1177/0885066610395678
Source DB: PubMed Journal: J Intensive Care Med ISSN: 0885-0666 Impact factor: 3.510