Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Identification of antitumor activity of pyrazole oxime ethers.

Literature DB >> 15922597

Identification of antitumor activity of pyrazole oxime ethers.

Hyun-Ja Park¹, Kyung Lee, Su-Jin Park, Bangle Ahn, Jong-Cheol Lee, Heeyeong Cho, Kee-In Lee.

Abstract

A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2005 PMID： 15922597 DOI： 10.1016/j.bmcl.2005.03.082

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

20 in total

1. 5-(4-tert-Butyl-benzyl-sulfan-yl)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde.

Authors: Chen-Yi Wang
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2007-12-12

2. N-[(3-Methyl-5-phen-oxy-1-phenyl-pyrazol-4-yl)carbon-yl]-N'-(5-propyl-1,3,4-thia-diazol-2-yl)thio-urea.

Authors: Yan-Rong Sun; Gang Liu; Chen-Jiang Liu; Yan-Ping Li
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2008-01-09

3. Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.

Authors: Fadi M Awadallah; Gary A Piazza; Bernard D Gary; Adam B Keeton; Joshua C Canzoneri
Journal: Eur J Med Chem Date: 2013-10-09 Impact factor: 6.514

4. Synthesis and antifungal activity of novel pyrazolecarboxamide derivatives containing a hydrazone moiety.

Authors: Jian Wu; Jian Wang; Deyu Hu; Ming He; Linhong Jin; Baoan Song
Journal: Chem Cent J Date: 2012-05-30 Impact factor: 4.215

5. Three-dimensional quantitative structure activity relationship (QSAR) of cytotoxic active 3,5-diaryl-4,5-dihydropyrazole analogs: a comparative molecular field analysis (CoMFA) revisited study.

Authors: Abdel-Sattar S Hamad Elgazwy; Daliah S Soliman; Saad R Atta-Allah; Diaa A Ibrahim
Journal: Chem Cent J Date: 2012-05-30 Impact factor: 4.215

10. Crystal structure of (E)-4-{[2-(2,4-di-nitro-phen-yl)hydrazin-1-yl-idene]meth-yl}-3-methyl-1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole.

Authors: Joel T Mague; Shaaban K Mohamed; Mehmet Akkurt; Hussein M S El-Kashef; Mustafa R Albayati
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2014-11-08

Identification of antitumor activity of pyrazole oxime ethers.

1. 5-(4-tert-Butyl-benzyl-sulfan-yl)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde.

2. N-[(3-Methyl-5-phen-oxy-1-phenyl-pyrazol-4-yl)carbon-yl]-N'-(5-propyl-1,3,4-thia-diazol-2-yl)thio-urea.

3. Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.

4. Synthesis and antifungal activity of novel pyrazolecarboxamide derivatives containing a hydrazone moiety.

5. Three-dimensional quantitative structure activity relationship (QSAR) of cytotoxic active 3,5-diaryl-4,5-dihydropyrazole analogs: a comparative molecular field analysis (CoMFA) revisited study.

6. 3-(4-Bromo-phen-yl)-5-[4-(dimethyl-amino)-phen-yl]-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

7. (E)-3-Methyl-5-(4-methyl-phen-oxy)-1-phenyl-1H-pyrazole-4-carbaldehyde O-[(2-chloro-1,3-thia-zol-5-yl)meth-yl]oxime.

8. 1-(4-Methyl-phenyl-sulfon-yl)-5-phenyl-4,5-dihydro-1H-pyrazole.

9. Synthesis of new pyrazolyl-2, 4-thiazolidinediones as antibacterial and antifungal agents.

10. Crystal structure of (E)-4-{[2-(2,4-di-nitro-phen-yl)hydrazin-1-yl-idene]meth-yl}-3-methyl-1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole.