| Literature DB >> 15922525 |
Miao Miao Xi1, San Qi Zhang, Xin Yi Wang, Kun Quan Fang, Yi Gu.
Abstract
Pectin-ketoprofen (PT-KP) prodrug with the potential for colon targeted delivery has been evaluated. A sensitive HPLC method was established for the determination of concentration of ketoprofen (KP) in rats. This method was also used to evaluate the colon targeting property of PT-KP. KP or PT-KP was given to rats by oral administration at a dosage of 10mg/kg. Plasma and the different parts of gastrointestinal (GI) tract were taken after 2, 4, 6, 8, 10 and 12h of oral administration of KP or PT-KP to rats and the concentration of KP was measured by HPLC. Preliminary experiments show KP distributes mainly in stomach, proximal small intestine and distal small intestine. However, KP released from PT-KP mainly distributes in cecum and colon. Therefore, this approach suggests that PT-KP prodrug has a good colon targeting property.Entities:
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Year: 2005 PMID： 15922525 DOI： 10.1016/j.ijpharm.2005.04.012
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875