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Literature DB >> 1592235

The proximal end of mouse chromosome 17: new molecular markers identify a deletion associated with quakingviable.

Abstract

Five randomly identified cosmids have been mapped proximal to the Leh66D locus on mouse chromosome 17. Two of these cosmids, Au10 and Au119, map near the neurological mutation quaking. Au119 is deleted in qkviable/qkviable DNA, whereas Au10 is not. Au76 maps to a gene-rich region near the Time locus. The Au76 locus encodes a member of a low copy gene family expressed in embryos, the adult central nervous system and testis. A second member of this family has been mapped to chromosome 15 near c-sis (PDGF-B). At the centromeric end of chromosome 17, Au116 maps near the Tu1 locus, and along with Au217rs identifies a region of unusually high recombinational activity between t-haplotypes and wild-type chromosomes. Au217I and II map to the large inverted repeats found at the proximal end of the wild-type chromosome. In addition, the Au217I and/or II loci encode testis transcripts not expressed from t-haplotypes.

Entities: Gene Species

Mesh：

Substances：
Chromatin
Genetic Markers

Year: 1992 PMID： 1592235 PMCID： PMC1204952

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

27 in total

1. New molecular markers for the distal end of the t-complex and their relationships to mutations affecting mouse development.

Authors: T Ebersole; F Lai; K Artzt
Journal: Genetics Date: 1992-05 Impact factor: 4.562

2. Pleiotropic action of the murine quaking locus: structure of the qkv allele.

Authors: T R King; W F Dove
Journal: Mamm Genome Date: 1991 Impact factor: 2.957

3. Observations on a set of radiation-induced dominant T-like mutations in the mouse.

Authors: D Bennett; L C Dunn; M Spiegelman; K Artzt; J Cookingham; E Schermerhorn
Journal: Genet Res Date: 1975-08 Impact factor: 1.588

4. Submegabase clusters of unstable tandem repeats unique to the Tla region of mouse t haplotypes.

Authors: H Uehara; T Ebersole; D Bennett; K Artzt
Journal: Genetics Date: 1990-12 Impact factor: 4.562

5. Hairpin-tail: a case of post-reductional gene action in the mouse egg.

Authors: D R JOHNSON
Journal: Genetics Date: 1974-04 Impact factor: 4.562

6. Abnormal spermiogenesis in quaking, a myelin-deficient mutant mouse.

Authors: W I Bennett; A M Gall; J L Southard; R L Sidman
Journal: Biol Reprod Date: 1971-08 Impact factor: 4.285

7. Deletion mapping of the t complex of chromosome 17 of the mouse.

Authors: R P Erickson; S E Lewis; K S Slusser
Journal: Nature Date: 1978-07-13 Impact factor: 49.962

8. The effects of a t-allele (tAE5) in the mouse on the lymphoid system and reproduction.

Authors: M Vojtísková; V Viklický; B Vorácová; S E Lewis; S Gluecksohn-Waelsch
Journal: J Embryol Exp Morphol Date: 1976-10

9. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.

Authors: D P Barlow; R Stöger; B G Herrmann; K Saito; N Schweifer
Journal: Nature Date: 1991-01-03 Impact factor: 49.962

10. MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM.

Authors: R L SIDMAN; M M DICKIE; S H APPEL
Journal: Science Date: 1964-04-17 Impact factor: 47.728

16 in total

1. New molecular markers for the distal end of the t-complex and their relationships to mutations affecting mouse development.

Authors: T Ebersole; F Lai; K Artzt
Journal: Genetics Date: 1992-05 Impact factor: 4.562

Review 2. Mouse chromosome 17.

Authors: L M Silver; K Artzt; D Barlow; K Fischer-Lindahl; M F Lyon; J Klein; L Snyder
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

The proximal end of mouse chromosome 17: new molecular markers identify a deletion associated with quakingviable.

1. New molecular markers for the distal end of the t-complex and their relationships to mutations affecting mouse development.

2. Pleiotropic action of the murine quaking locus: structure of the qkv allele.

3. Observations on a set of radiation-induced dominant T-like mutations in the mouse.

4. Submegabase clusters of unstable tandem repeats unique to the Tla region of mouse t haplotypes.

5. Hairpin-tail: a case of post-reductional gene action in the mouse egg.

6. Abnormal spermiogenesis in quaking, a myelin-deficient mutant mouse.

7. Deletion mapping of the t complex of chromosome 17 of the mouse.

8. The effects of a t-allele (tAE5) in the mouse on the lymphoid system and reproduction.

9. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.

10. MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM.

1. New molecular markers for the distal end of the t-complex and their relationships to mutations affecting mouse development.

Review 2. Mouse chromosome 17.

Review 3. Insights into the structural basis of RNA recognition by STAR domain proteins.

4. A new spontaneous deletion on chromosome 17 including brachyury.

5. Detailed physical and genetic mapping in the region of plasminogen, D17Rp17e, and quaking.

6. A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination.

7. Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant.

8. Mammalian developmental genetics in the twentieth century.

9. Structural analysis of the quaking homodimerization interface.

10. The neurological mutant quaking(viable) is Parkin deficient.