Literature DB >> 15922338

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals.

Raphael R Prattali1, Guilherme C Barreiro, Caio T Caliseo, Felipe Y Fugiwara, Mirian Ueno, Patrícia O Prada, Licio A Velloso, Mario J A Saad, José B C Carvalheira.   

Abstract

In this study, we demonstrate that pretreatment with aspirin inhibits GH-induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRS/PI(3)kinase pathway and a reduction in IRS-1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. Overall, these results provide new insights into the mechanism of GH-induced insulin resistance.

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Year:  2005        PMID： 15922338     DOI： 10.1016/j.febslet.2005.04.075

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation.

Authors:  Srinivas Ayyadevara; Meenakshisundaram Balasubramaniam; Samuel Kakraba; Ramani Alla; Jawahar L Mehta; Robert J Shmookler Reis
Journal:  Antioxid Redox Signal       Date:  2017-06-28       Impact factor: 8.401

2.  Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity.

Authors:  Yash Chhabra; Caroline N Nelson; Monika Plescher; Johanna L Barclay; Aaron G Smith; Sof Andrikopoulos; Salvatore Mangiafico; David J Waxman; Andrew J Brooks; Michael J Waters
Journal:  FASEB J       Date:  2019-02-19       Impact factor: 5.191

3.  Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice.

Authors:  Audreen Louis; Andrzej Bartke; Michal M Masternak
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-03-03       Impact factor: 6.053

4.  Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt.

Authors:  M A Carvalho-Filho; E R Ropelle; R J Pauli; D E Cintra; D M L Tsukumo; L R Silveira; R Curi; J B C Carvalheira; L A Velloso; M J A Saad
Journal:  Diabetologia       Date:  2009-11       Impact factor: 10.122

5.  Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation.

Authors:  Eduardo R Ropelle; José R Pauli; Patrícia O Prada; Cláudio T de Souza; Paty K Picardi; Marcel C Faria; Dennys E Cintra; Maria Fernanda de A Fernandes; Marcelo B Flores; Lício A Velloso; Mario J A Saad; José B C Carvalheira
Journal:  J Physiol       Date:  2006-09-28       Impact factor: 5.182

6.  Insulin signaling in the heart is impaired by growth hormone: a direct and early event.

Authors:  Marina C Muñoz; Verónica G Piazza; Valeria Burghi; Jorge F Giani; Carolina S Martinez; Nadia S Cicconi; Nadia V Muia; Yimin Fang; Sergio Lavandero; Ana I Sotelo; Andrzej Bartke; Patricia A Pennisi; Fernando P Dominici; Johanna G Miquet
Journal:  J Mol Endocrinol       Date:  2022-06-23       Impact factor: 4.869

7.  Comparison of pulsatile vs. continuous administration of human placental growth hormone in female C57BL/6J mice.

Authors:  Shutan Liao; Mark H Vickers; Angharad Evans; Joanna L Stanley; Philip N Baker; Jo K Perry
Journal:  Endocrine       Date:  2016-08-11       Impact factor: 3.633

8.  Clinical diagnosis for dusk phenomenon of diabetes.

Authors:  Sina Du; Min-Jia Shi; Zhan-Zhan Sun; Wei Li
Journal:  Medicine (Baltimore)       Date:  2018-08       Impact factor: 1.817
  8 in total

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