| Literature DB >> 17008371 |
Eduardo R Ropelle1, José R Pauli, Patrícia O Prada, Cláudio T de Souza, Paty K Picardi, Marcel C Faria, Dennys E Cintra, Maria Fernanda de A Fernandes, Marcelo B Flores, Lício A Velloso, Mario J A Saad, José B C Carvalheira.
Abstract
Lifestyle interventions including exercise programmes are cornerstones in the prevention of obesity-related diabetes. In this study, we demonstrate that a single bout of exercise inhibits high-fat diet-induced insulin resistance. Diet-induced obesity (DIO) increased the expression and activity of the protein tyrosine phosphatase 1B (PTP1B) and attenuated insulin signalling in gastrocnemius muscle of rats, a phenomenon which was reversed by a single session of exercise. In addition, DIO was observed to lead to serine phosphorylation of insulin receptor substrate 1 (IRS-1), which was also reversed by exercise in muscle in parallel with a reduction in c-Jun N-terminal kinase (JNK) activity. Thus, acute exercise increased the insulin sensitivity during high-fat feeding in obese rats. Overall, these results provide new insights into the mechanism by which exercise restores insulin sensitivity.Entities:
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Year: 2006 PMID： 17008371 PMCID： PMC1890392 DOI： 10.1113/jphysiol.2006.120006
Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182