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Literature DB >> 15914357

Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes.

Atsushi Iwama¹, Hideyuki Oguro, Masamitsu Negishi, Yuko Kato, Hiromitsu Nakauchi.

Abstract

Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi-1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.

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Year: 2005 PMID： 15914357 DOI： 10.1532/IJH97.05011

Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490

54 in total

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Authors: T Mahmoudi; C P Verrijzer
Journal: Oncogene Date: 2001-05-28 Impact factor: 9.867

2. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.

Authors: Anna V Molofsky; Ricardo Pardal; Toshihide Iwashita; In-Kyung Park; Michael F Clarke; Sean J Morrison
Journal: Nature Date: 2003-10-22 Impact factor: 49.962

Review 3. Bmi1, stem cells, and senescence regulation.

Authors: In-Kyung Park; Sean J Morrison; Michael F Clarke
Journal: J Clin Invest Date: 2004-01 Impact factor: 14.808

Review 4. Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis.

Authors: Julie Lessard; Guy Sauvageau
Journal: Exp Hematol Date: 2003-07 Impact factor: 3.084

5. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25.

Authors: O Tetsu; H Ishihara; R Kanno; M Kamiyasu; H Inoue; T Tokuhisa; M Taniguchi; M Kanno
Journal: Immunity Date: 1998-10 Impact factor: 31.745

Review 6. Epigenetics and cancer.

Authors: Anders H Lund; Maarten van Lohuizen
Journal: Genes Dev Date: 2004-10-01 Impact factor: 11.361

7. Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression.

Authors: T Akasaka; M van Lohuizen; N van der Lugt; Y Mizutani-Koseki; M Kanno; M Taniguchi; M Vidal; M Alkema; A Berns; H Koseki
Journal: Development Date: 2001-05 Impact factor: 6.868

Review 8. Polycomb, epigenomes, and control of cell identity.

Authors: Valerio Orlando
Journal: Cell Date: 2003-03-07 Impact factor: 41.582

9. Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.

Authors: Y Takihara; D Tomotsune; M Shirai; Y Katoh-Fukui; K Nishii; M A Motaleb; M Nomura; R Tsuchiya; Y Fujita; Y Shibata; T Higashinakagawa; K Shimada
Journal: Development Date: 1997-10 Impact factor: 6.868

10. Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs.

Authors: Hina Takano; Hideo Ema; Kazuhiro Sudo; Hiromitsu Nakauchi
Journal: J Exp Med Date: 2004-01-26 Impact factor: 14.307

13 in total

1. HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells.

Authors: Haojian Zhang; Huawei Li; Hualin S Xi; Shaoguang Li
Journal: Blood Date: 2012-01-24 Impact factor: 22.113

2. Unique composition of polycomb repressive complex 1 in hematopoietic stem cells.

Authors: Yuko Kato; Haruhiko Koseki; Miguel Vidal; Hiromitsu Nakauchi; Atsushi Iwama
Journal: Int J Hematol Date: 2007-02 Impact factor: 2.490

Review 3. Epigenetic regulation of hematopoiesis.

Authors: Goro Sashida; Atsushi Iwama
Journal: Int J Hematol Date: 2012-09-29 Impact factor: 2.490

4. BMI-1, a promising therapeutic target for human cancer.

Authors: Min-Cong Wang; Chun-Li Li; Jie Cui; Min Jiao; Tao Wu; L I Jing; Ke-Jun Nan
Journal: Oncol Lett Date: 2015-06-11 Impact factor: 2.967

5. The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function.

Authors: Yue Gu; Amanda E Jones; Wei Yang; Shanrun Liu; Qian Dai; Yudong Liu; C Scott Swindle; Dewang Zhou; Zhuo Zhang; Thomas M Ryan; Tim M Townes; Christopher A Klug; Dongquan Chen; Hengbin Wang
Journal: Proc Natl Acad Sci U S A Date: 2015-12-22 Impact factor: 11.205

6. The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.

Authors: Zhenhua Yang; Jonathan Augustin; Chenbei Chang; Jing Hu; Kushani Shah; Chia-Wei Chang; Tim Townes; Hao Jiang
Journal: Blood Date: 2014-08-18 Impact factor: 22.113

10. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.

Authors: Hideyuki Oguro; Atsushi Iwama; Yohei Morita; Takehiko Kamijo; Maarten van Lohuizen; Hiromitsu Nakauchi
Journal: J Exp Med Date: 2006-09-05 Impact factor: 14.307