Literature DB >> 15911256

Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines.

Xiangshu Xiao1, Ze-Hong Miao, Smitha Antony, Yves Pommier, Mark Cushman.   

Abstract

Dihydroindenoisoquinolines are analogs of cytotoxic indenoisoquinoline topoisomerase I (Top1) inhibitors, exhibiting potent cytotoxicity but weak inhibitory activity toward Top1. Through COMPARE analysis, cytotoxicity studies in Top1-deficient cells, chemical synthesis and biological evaluation of methylated dihydroindenoisoquinoline 5, we demonstrated that dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines in cancer cells.

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Year:  2005        PMID： 15911256     DOI： 10.1016/j.bmcl.2005.03.101

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.

Authors:  Andrew Morrell; Smitha Antony; Glenda Kohlhagen; Yves Pommier; Mark Cushman
Journal:  J Med Chem       Date:  2006-12-28       Impact factor: 7.446

2.  A Facile method to transform trans-4-carboxy-3,4-dihydro-3-phenyl- 1(2H)-isoquinolones to indeno[1,2-c]isoquinolines.

Authors:  Xiangshu Xiao; Mark Cushman
Journal:  J Org Chem       Date:  2005-08-05       Impact factor: 4.354

3.  Application of sequential Cu(I)/Pd(0)-catalysis to solution-phase parallel synthesis of combinatorial libraries of dihydroindeno[1,2-c]isoquinolines.

Authors:  Sarvesh Kumar; Thomas O Painter; Benoy K Pal; Benjamin Neuenswander; Helena C Malinakova
Journal:  ACS Comb Sci       Date:  2011-07-20       Impact factor: 3.784

4.  The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives.

Authors:  Yves Pommier; Mark Cushman
Journal:  Mol Cancer Ther       Date:  2009-04-21       Impact factor: 6.261

5.  Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400).

Authors:  Peng-Cheng Lv; Mohamed S A Elsayed; Keli Agama; Christophe Marchand; Yves Pommier; Mark Cushman
Journal:  J Med Chem       Date:  2016-04-20       Impact factor: 7.446

6.  Total synthesis and biological evaluation of 22-hydroxyacuminatine.

Authors:  Xiangshu Xiao; Smitha Antony; Yves Pommier; Mark Cushman
Journal:  J Med Chem       Date:  2006-02-23       Impact factor: 7.446

Review 7.  DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition.

Authors:  Yves Pommier
Journal:  Chem Rev       Date:  2009-07       Impact factor: 60.622

8.  Sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol for the synthesis of indenoisoquinolines.

Authors:  Thiruvellore Thatai Jayanth; Lei Zhang; Thomas S Johnson; Helena C Malinakova
Journal:  Org Lett       Date:  2009-02-19       Impact factor: 6.005

9.  Enantioselective synthesis of quaternary 3,4-dihydroisoquinolinones via Heck carbonylation reactions: development and application to the synthesis of Minalrestat analogues.

Authors:  Cang Cheng; Bin Wan; Bo Zhou; Yichao Gu; Yanghui Zhang
Journal:  Chem Sci       Date:  2019-09-03       Impact factor: 9.825
  9 in total

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