| Literature DB >> 1590990 |
Abstract
Rejection of transplanted tissue allografts results from T-cell recognition of histocompatibility antigens expressed by cells of the donor graft. This review focuses on the phenotype, specificity, and function of the T cells mediating rejection responses against skin allografts, and on the immune mechanisms by which host T cells are either activated or rendered non-responsive by cellular populations within the graft. We review the cellular basis for rejection responses across limited class-I and class-II major histocompatibility differences, as well as the specificity of the rejection response itself.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1590990 DOI： 10.1146/annurev.iy.10.040192.002001
Source DB: PubMed Journal: Annu Rev Immunol ISSN： 0732-0582 Impact factor: 28.527