Literature DB >> 15908421

Immunological evaluation and cellular location analysis of the TprI antigen of Treponema pallidum subsp. pallidum.

Lorenzo Giacani1, Vittorio Sambri, Antonella Marangoni, Francesca Cavrini, Elisa Storni, Manuela Donati, Silvia Corona, Paolo Lanzarini, Roberto Cevenini.   

Abstract

The TprI antigen of Treponema pallidum subsp. pallidum is a putative virulence factor predicted to be located in the outer membrane of the syphilis spirochete. In this study, we analyzed the immune response against TprI and its subunits in sera collected both from rabbits experimentally infected with the Nichols strain and from patients with syphilis, showing a different pattern of reactivity toward the antigen in these two groups of samples. The protective ability of recombinant TprI and its hypothetical outer membrane location were also investigated. Although no rabbit was protected after challenge, immunoelectron microscopy results, to be further investigated, were compatible with the outer membrane location of the antigen.

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Year:  2005        PMID： 15908421      PMCID： PMC1111852          DOI： 10.1128/IAI.73.6.3817-3822.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

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4.  Macrophage-mediated killing of opsonized Treponema pallidum.

Authors:  S A Baker-Zander; S A Lukehart
Journal:  J Infect Dis       Date:  1992-01       Impact factor: 5.226

5.  The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum.

Authors:  D L Cox; P Chang; A W McDowall; J D Radolf
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

6.  Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions.

Authors:  S A Lukehart; S A Baker-Zander; R M Lloyd; S Sell
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7.  Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection.

Authors:  Arturo Centurion-Lara; Rebecca E LaFond; Karin Hevner; Charmie Godornes; Barbara J Molini; Wesley C Van Voorhis; Sheila A Lukehart
Journal:  Mol Microbiol       Date:  2004-06       Impact factor: 3.501

8.  Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum.

Authors:  J D Radolf; M V Norgard; W W Schulz
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

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3.  Length of guanosine homopolymeric repeats modulates promoter activity of subfamily II tpr genes of Treponema pallidum ssp. pallidum.

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7.  Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis.

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8.  Laboratory diagnosis of syphilis with automated immunoassays.

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10.  Evaluation of the BioPlex 2200 syphilis system as a first-line method of reverse-sequence screening for syphilis diagnosis.

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