| Literature DB >> 15908212 |
Jun-Feng He1, Liu-Hong Yun, Ri-Fang Yang, Zhi-Yong Xiao, Jun-Ping Cheng, Wen-Xia Zhou, Yong-Xiang Zhang.
Abstract
A series of novel quinoline-3-carboxamide derivatives were synthesized and evaluated for their immunomodulatory activity. The compounds were tested in vitro for effects on spleen lymphocyte proliferation and TNF-alpha production by macrophage. Three compounds showed immunomodulatory profiles similar to and more potent than those of linomide and FR137316 and were selected for further pharmacological studies in vivo.Entities:
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Year: 2005 PMID： 15908212 DOI： 10.1016/j.bmcl.2005.04.040
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823