Literature DB >> 15907921

Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.

James F Tobin1, Anthony J Celeste.   

Abstract

Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic approaches can increase muscle mass in a number of animal models of human disease, including muscular dystrophy.

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Year:  2005        PMID： 15907921     DOI： 10.1016/j.coph.2005.01.011

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  24 in total

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Review 2.  microRNAs and muscle disorders.

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Review 3.  Advanced technologies for genomic analysis in farm animals and its application for QTL mapping.

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4.  Reduced serum myostatin concentrations associated with genetic muscle disease progression.

Authors:  Peter M Burch; Oksana Pogoryelova; Joe Palandra; Richard Goldstein; Donald Bennett; Lori Fitz; Michela Guglieri; Chiara Marini Bettolo; Volker Straub; Teresinha Evangelista; Hendrik Neubert; Hanns Lochmüller; Carl Morris
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Review 5.  Muscle wasting and cachexia in heart failure: mechanisms and therapies.

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6.  An evolutionarily conserved Myostatin proximal promoter/enhancer confers basal levels of transcription and spatial specificity in vivo.

Authors:  Carla Vermeulen Carvalho Grade; Mônica Senna Salerno; Frank R Schubert; Susanne Dietrich; Lúcia Elvira Alvares
Journal:  Dev Genes Evol       Date:  2010-01-06       Impact factor: 0.900

7.  Hydrodynamic limb vein injection of adeno-associated virus serotype 8 vector carrying canine myostatin propeptide gene into normal dogs enhances muscle growth.

Authors:  Chunping Qiao; Juan Li; Hui Zheng; Janet Bogan; Jianbin Li; Zhenhua Yuan; Cheng Zhang; Dan Bogan; Joe Kornegay; Xiao Xiao
Journal:  Hum Gene Ther       Date:  2009-01       Impact factor: 5.695

8.  Cytotoxic aggregation and amyloid formation by the myostatin precursor protein.

Authors:  Carlene S Starck; Andrew J Sutherland-Smith
Journal:  PLoS One       Date:  2010-02-11       Impact factor: 3.240

9.  Tendons of myostatin-deficient mice are small, brittle, and hypocellular.

Authors:  Christopher L Mendias; Konstantin I Bakhurin; John A Faulkner
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-27       Impact factor: 11.205

Review 10.  Sarcopenia: etiology, clinical consequences, intervention, and assessment.

Authors:  T Lang; T Streeper; P Cawthon; K Baldwin; D R Taaffe; T B Harris
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