George A Kelley1, K S Kelley. 1. Meta-Analytic Research Group, Department of Community Medicine, Robert C. Byrd Health Sciences Center, School of Medicine, West Virginia University, P.O. Box 9190, Morgantown, WV 26506-9190, USA. gkelley@hsc.wvu.edu
Abstract
PURPOSE: Use the meta-analytic approach to examine the effects of aerobic exercise on high-density lipoprotein two cholesterol (HDL2-C) in adults. STUDY SOURCES: (1) Computerized literature searches; (2) cross-referencing from retrieved articles; (3) hand-searching; and (4) expert review of our reference list. STUDY SELECTION: (1) Randomized controlled trials; (2) aerobic exercise > or = 8 weeks; (3) adults > or = 18 years of age; (4) studies published in journal, dissertation, or master's thesis format; (5) studies published in the English-language between January 1, 1955 and January 1, 2003; and (6) assessment of HDL2-C in the fasting state. DATA ABSTRACTION: All coding conducted by both authors, independent of each other. Discrepancies were resolved by consensus. RESULTS: Nineteen randomized controlled trials representing 20 HDL2-C outcomes from 984 males and females (516 exercise, 468 control) were pooled for analysis. Using random-effects modeling and bootstrap confidence intervals (BCI), a statistically significant increase of approximately 11% was observed for HDL2-C (X +/- S.E.M., 2.6 +/- 0.9 mg/dl, 95% BCI, 1.0-4.4 mg/dl). With each study deleted from the model once, results remained statistically significant. Increases in HDL2-C were independent of decreases in body weight, body mass index (kg/m2), and percent body fat. CONCLUSION: Aerobic exercise increases HDL2-C in adults.
PURPOSE: Use the meta-analytic approach to examine the effects of aerobic exercise on high-density lipoprotein two cholesterol (HDL2-C) in adults. STUDY SOURCES: (1) Computerized literature searches; (2) cross-referencing from retrieved articles; (3) hand-searching; and (4) expert review of our reference list. STUDY SELECTION: (1) Randomized controlled trials; (2) aerobic exercise > or = 8 weeks; (3) adults > or = 18 years of age; (4) studies published in journal, dissertation, or master's thesis format; (5) studies published in the English-language between January 1, 1955 and January 1, 2003; and (6) assessment of HDL2-C in the fasting state. DATA ABSTRACTION: All coding conducted by both authors, independent of each other. Discrepancies were resolved by consensus. RESULTS: Nineteen randomized controlled trials representing 20 HDL2-C outcomes from 984 males and females (516 exercise, 468 control) were pooled for analysis. Using random-effects modeling and bootstrap confidence intervals (BCI), a statistically significant increase of approximately 11% was observed for HDL2-C (X +/- S.E.M., 2.6 +/- 0.9 mg/dl, 95% BCI, 1.0-4.4 mg/dl). With each study deleted from the model once, results remained statistically significant. Increases in HDL2-C were independent of decreases in body weight, body mass index (kg/m2), and percent body fat. CONCLUSION: Aerobic exercise increases HDL2-C in adults.
Authors: R Rauramaa; J T Salonen; K Kukkonen-Harjula; K Seppänen; E Seppälä; H Vapaatalo; J K Huttunen Journal: Br Med J (Clin Res Ed) Date: 1984-02-25
Authors: P D Wood; W L Haskell; S N Blair; P T Williams; R M Krauss; F T Lindgren; J J Albers; P H Ho; J W Farquhar Journal: Metabolism Date: 1983-01 Impact factor: 8.694
Authors: Manuel Teixeira Veríssimo; António Aragão; Ana Sousa; Benilde Barbosa; Helena Ribeiro; Dário Costa; Maria Helena Saldanha Journal: Rev Port Cardiol Date: 2002-10 Impact factor: 1.374
Authors: Robert H Eckel; John M Jakicic; Jamy D Ard; Janet M de Jesus; Nancy Houston Miller; Van S Hubbard; I-Min Lee; Alice H Lichtenstein; Catherine M Loria; Barbara E Millen; Cathy A Nonas; Frank M Sacks; Sidney C Smith; Laura P Svetkey; Thomas A Wadden; Susan Z Yanovski; Karima A Kendall; Laura C Morgan; Michael G Trisolini; George Velasco; Janusz Wnek; Jeffrey L Anderson; Jonathan L Halperin; Nancy M Albert; Biykem Bozkurt; Ralph G Brindis; Lesley H Curtis; David DeMets; Judith S Hochman; Richard J Kovacs; E Magnus Ohman; Susan J Pressler; Frank W Sellke; Win-Kuang Shen; Sidney C Smith; Gordon F Tomaselli Journal: Circulation Date: 2013-11-12 Impact factor: 29.690
Authors: M Garelnabi; E Veledar; J White-Welkley; N Santanam; J Abramson; W Weintraub; S Parthasarathy Journal: Nutr Metab Cardiovasc Dis Date: 2011-07-22 Impact factor: 4.222
Authors: Jan Kretzschmar; Dianne M Babbitt; Keith M Diaz; Deborah L Feairheller; Kathleen M Sturgeon; Amanda M Perkins; Praveen Veerabhadrappa; Sheara T Williamson; Chenyi Ling; Hojun Lee; Heather Grimm; Sunny R Thakkar; Deborah L Crabbe; Mohammed A Kashem; Michael D Brown Journal: Menopause Date: 2014-06 Impact factor: 2.953
Authors: Christoph U Correll; Peter Manu; Vladimir Olshanskiy; Barbara Napolitano; John M Kane; Anil K Malhotra Journal: JAMA Date: 2009-10-28 Impact factor: 56.272
Authors: Victor Hideaki Goto Hirai; Beatriz Maria Dos Santos Santiago Ribeiro; Thiago Braz Novaes; Júlia Trevisan Martins; Elen Ferraz Teston Journal: Rev Bras Med Trab Date: 2020-01-09