Literature DB >> 15901712

Structure-activity analysis of microcinJ25: distinct parts of the threaded lasso molecule are responsible for interaction with bacterial RNA polymerase.

Ekaterina Semenova1, Yulia Yuzenkova, Jean Peduzzi, Sylvie Rebuffat, Konstantin Severinov.   

Abstract

Peptide microcin J25 (MccJ25) inhibits bacterial RNA polymerase. We show that thermolysin-cleaved MccJ25 and MccJ25 lacking amino acids 13 to 17 also inhibit transcription. Our data and structural analysis of intact and thermolysin-digested MccJ25 suggest that distinct regions of MccJ25 are involved in transcription inhibition and cell entry.

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Year:  2005        PMID： 15901712      PMCID： PMC1112051          DOI： 10.1128/JB.187.11.3859-3863.2005

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  20 in total

1.  Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.

Authors:  M A Delgado; M R Rintoul; R N Farías; R A Salomón
Journal:  J Bacteriol       Date:  2001-08       Impact factor: 3.490

2.  Microcin 25, a novel antimicrobial peptide produced by Escherichia coli.

Authors:  R A Salomón; R N Farías
Journal:  J Bacteriol       Date:  1992-11       Impact factor: 3.490

3.  Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot.

Authors:  Marvin J Bayro; Jayanta Mukhopadhyay; G V T Swapna; Janet Y Huang; Li-Chung Ma; Elena Sineva; Philip E Dawson; Gaetano T Montelione; Richard H Ebright
Journal:  J Am Chem Soc       Date:  2003-10-15       Impact factor: 15.419

4.  Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone.

Authors:  K Johan Rosengren; Richard J Clark; Norelle L Daly; Ulf Göransson; Alun Jones; David J Craik
Journal:  J Am Chem Soc       Date:  2003-10-15       Impact factor: 15.419

5.  Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25.

Authors:  Karen Adelman; Julia Yuzenkova; Arthur La Porta; Nikolay Zenkin; Jookyung Lee; John T Lis; Sergei Borukhov; Michelle D Wang; Konstantin Severinov
Journal:  Mol Cell       Date:  2004-06-18       Impact factor: 17.970

6.  Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays antimicrobial activity.

Authors:  Alain Blond; Michel Cheminant; Delphine Destoumieux-Garzón; Isabelle Ségalas-Milazzo; Jean Peduzzi; Christophe Goulard; Sylvie Rebuffat
Journal:  Eur J Biochem       Date:  2002-12

7.  The FhuA protein is involved in microcin 25 uptake.

Authors:  R A Salomón; R N Farías
Journal:  J Bacteriol       Date:  1993-12       Impact factor: 3.490

8.  Structure of thermolysin cleaved microcin J25: extreme stability of a two-chain antimicrobial peptide devoid of covalent links.

Authors:  K Johan Rosengren; Alain Blond; Carlos Afonso; Jean-Claude Tabet; Sylvie Rebuffat; David J Craik
Journal:  Biochemistry       Date:  2004-04-27       Impact factor: 3.162

9.  Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail.

Authors:  Kelly-Anne Wilson; Markus Kalkum; Jennifer Ottesen; Julia Yuzenkova; Brian T Chait; Robert Landick; Tom Muir; Konstantin Severinov; Seth A Darst
Journal:  J Am Chem Soc       Date:  2003-10-15       Impact factor: 15.419

10.  Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.

Authors:  Jayanta Mukhopadhyay; Elena Sineva; Jennifer Knight; Ronald M Levy; Richard H Ebright
Journal:  Mol Cell       Date:  2004-06-18       Impact factor: 17.970
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  10 in total

1.  The iron-siderophore transporter FhuA is the receptor for the antimicrobial peptide microcin J25: role of the microcin Val11-Pro16 beta-hairpin region in the recognition mechanism.

Authors:  Delphine Destoumieux-Garzón; Sophie Duquesne; Jean Peduzzi; Christophe Goulard; Michel Desmadril; Lucienne Letellier; Sylvie Rebuffat; Pascale Boulanger
Journal:  Biochem J       Date:  2005-08-01       Impact factor: 3.857

2.  Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state.

Authors:  Hassanul G Choudhury; Zhen Tong; Indran Mathavan; Yanyan Li; So Iwata; Séverine Zirah; Sylvie Rebuffat; Hendrik W van Veen; Konstantinos Beis
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-11       Impact factor: 11.205

Review 3.  RiPP antibiotics: biosynthesis and engineering potential.

Authors:  Graham A Hudson; Douglas A Mitchell
Journal:  Curr Opin Microbiol       Date:  2018-03-10       Impact factor: 7.934

4.  Computational design of the lasso peptide antibiotic microcin J25.

Authors:  Si Jia Pan; Wai Ling Cheung; Ho Ki Fung; Christodoulos A Floudas; A James Link
Journal:  Protein Eng Des Sel       Date:  2010-11-23       Impact factor: 1.650

5.  Potential applicability of chymotrypsin-susceptible microcin J25 derivatives to food preservation.

Authors:  María Fernanda Pomares; Raúl A Salomón; Olga Pavlova; Konstantin Severinov; Ricardo Farías; Paula A Vincent
Journal:  Appl Environ Microbiol       Date:  2009-07-10       Impact factor: 4.792

6.  Systematic structure-activity analysis of microcin J25.

Authors:  Olga Pavlova; Jayanta Mukhopadhyay; Elena Sineva; Richard H Ebright; Konstantin Severinov
Journal:  J Biol Chem       Date:  2008-07-16       Impact factor: 5.157

7.  Multi-omics Comparative Analysis of Streptomyces Mutants Obtained by Iterative Atmosphere and Room-Temperature Plasma Mutagenesis.

Authors:  Tan Liu; Zhiyong Huang; Xi Gui; Wei Xiang; Yubo Jin; Jun Chen; Jing Zhao
Journal:  Front Microbiol       Date:  2021-01-28       Impact factor: 5.640

8.  Structural and Functional Basis for Lipid Synergy on the Activity of the Antibacterial Peptide ABC Transporter McjD.

Authors:  Shahid Mehmood; Valentina Corradi; Hassanul G Choudhury; Rohanah Hussain; Patrick Becker; Danny Axford; Severine Zirah; Sylvie Rebuffat; D Peter Tieleman; Carol V Robinson; Konstantinos Beis
Journal:  J Biol Chem       Date:  2016-08-23       Impact factor: 5.157

9.  Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD.

Authors:  Kiran Bountra; Gregor Hagelueken; Hassanul G Choudhury; Valentina Corradi; Kamel El Omari; Armin Wagner; Indran Mathavan; Séverine Zirah; Weixiao Yuan Wahlgren; D Peter Tieleman; Olav Schiemann; Sylvie Rebuffat; Konstantinos Beis
Journal:  EMBO J       Date:  2017-09-01       Impact factor: 11.598

10.  Chemical Modification of Microcin J25 Reveals New Insights on the Stereospecific Requirements for Antimicrobial Activity.

Authors:  Helena Martin-Gómez; Marta Jorba; Fernando Albericio; Miguel Viñas; Judit Tulla-Puche
Journal:  Int J Mol Sci       Date:  2019-10-17       Impact factor: 5.923
  10 in total

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