Literature DB >> 15899814

Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis.

Yi Tang1, Varalakshmi Katuri, Radhika Srinivasan, Franz Fogt, Robert Redman, Girish Anand, Anan Said, Thomas Fishbein, Michael Zasloff, E Premkumar Reddy, Bibhuti Mishra, Lopa Mishra.   

Abstract

Although transforming growth factor-beta (TGF-beta) is both a suppressor and promoter of tumorigenesis, its contribution to early tumor suppression and staging remains largely unknown. In search of the mechanism of early tumor suppression, we identified the adaptor protein ELF, a beta-spectrin from stem/progenitor cells committed to foregut lineage. ELF activates and modulates Smad4 activation of TGF-beta to confer cell polarity, to maintain cell architecture, and to inhibit epithelial-to-mesenchymal transition. Analysis of development of colon cancer in (adult) elf+/-/Smad4+/-, elf+/-, Smad4+/-, and gut epithelial cells from elf-/- mutant mouse embryos pinpoints the defect to hyperplasia/adenoma transition. Further analysis of the role of ELF in human colorectal cancer confirms reduced expression of ELF in Dukes' B1 stage tissues (P < 0.05) and of Smad4 in advanced colon cancers (P < 0.05). This study indicates that by modulating Smad 4, ELF has a key role in TGF-beta signaling in the suppression of early colon cancer.

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Year:  2005        PMID： 15899814     DOI： 10.1158/0008-5472.CAN-04-4585

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  47 in total

1.  The structure of the ankyrin-binding site of beta-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties.

Authors:  Paul R Stabach; Ivana Simonović; Miranda A Ranieri; Michael S Aboodi; Thomas A Steitz; Miljan Simonović; Jon S Morrow
Journal:  Blood       Date:  2009-01-23       Impact factor: 22.113

Review 2.  Targeting TGF-β signaling in cancer.

Authors:  Lior H Katz; Ying Li; Jiun-Sheng Chen; Nina M Muñoz; Avijit Majumdar; Jian Chen; Lopa Mishra
Journal:  Expert Opin Ther Targets       Date:  2013-05-07       Impact factor: 6.902

3.  Application of multiplex methylated-specific PCR with capillary electrophoresis to explore prognostic value of TSGs hypermethylation for hepatocellular carcinoma.

Authors:  Yuan Huang; Ling Wei; Ai-Min Sun; Bo Li; Cheng-Jun Sun; Wei-Bo Liang; Qiu-Ying Liu; Xiao-Qin Yu; Jing-Yang He; Yang Qin
Journal:  J Clin Lab Anal       Date:  2018-03-07       Impact factor: 2.352

4.  New Therapeutics Targeting Colon Cancer Stem Cells.

Authors:  Arun Thenappan; Ying Li; Kirti Shetty; Lynt Johnson; E P Reddy; Lopa Mishra
Journal:  Curr Colorectal Cancer Rep       Date:  2009-10-01

5.  Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression.

Authors:  V Katuri; Y Tang; E P Reddy; C Li; W Jogunoori; C-X Deng; A Rashid; A N Sidawy; S Evans; B Mishra; L Mishra
Journal:  Oncogene       Date:  2006-03-23       Impact factor: 9.867

6.  CEACAM1 long cytoplasmic domain isoform is associated with invasion and recurrence of hepatocellular carcinoma.

Authors:  Shigehisa Kiriyama; Shozo Yokoyama; Masaki Ueno; Shinya Hayami; Junji Ieda; Naoyuki Yamamoto; Shunsuke Yamaguchi; Yasuyuki Mitani; Yasushi Nakamura; Masaji Tani; Lopa Mishra; John E Shively; Hiroki Yamaue
Journal:  Ann Surg Oncol       Date:  2014-01-06       Impact factor: 5.344

7.  Epigenetic silencing of beta-spectrin, a TGF-beta signaling/scaffolding protein in a human cancer stem cell disorder: Beckwith-Wiedemann syndrome.

Authors:  Zhi-Xing Yao; Wilma Jogunoori; Sanaa Choufani; Asif Rashid; Tiffany Blake; Wenguo Yao; Peter Kreishman; Rupen Amin; Anton A Sidawy; Stephen R T Evans; Milton Finegold; E Premkumar Reddy; Bibhuti Mishra; Rosanna Weksberg; Rakesh Kumar; Lopa Mishra
Journal:  J Biol Chem       Date:  2010-08-25       Impact factor: 5.157

8.  Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis.

Authors:  Hye Jung Baek; Sung Chul Lim; Krit Kitisin; Wilma Jogunoori; Yi Tang; M Blair Marshall; Bibhuti Mishra; Tae Hyun Kim; Kwan Ho Cho; Sang Soo Kim; Lopa Mishra
Journal:  Hepatology       Date:  2008-10       Impact factor: 17.425

9.  Transforming growth factor beta suppresses beta-catenin/Wnt signaling and stimulates an adhesion response in human colon carcinoma cells in a Smad4/DPC4 independent manner.

Authors:  Huijun Wang; Shanthi Rajan; Guangming Liu; Subhas Chakrabarty
Journal:  Cancer Lett       Date:  2008-03-25       Impact factor: 8.679

Review 10.  Smad4-mediated TGF-beta signaling in tumorigenesis.

Authors:  Guan Yang; Xiao Yang
Journal:  Int J Biol Sci       Date:  2010-01-01       Impact factor: 6.580
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